H2AX and TOPORS

  • Number of citations of the paper that reports this interaction (PubMedID 22972498)
  • 3
  • Data Source:
  • BioGRID (enzymatic study)

H2AX

TOPORS

Description H2A.X variant histone TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Early spontaneous preterm birth ( 31194736)
  • Immune response to smallpox vaccine (IL-6) ( 22610502)
  • Metabolite levels ( 23823483)
Interacting Genes 45 interacting genes: A2M ACTB ALG9 ATM ATR BARD1 BAZ1B BMI1 BRCA1 BRCA2 BRD1 CALM1 COPG1 DDX21 DHX9 EYA1 HUWE1 KAT5 MASP1 MDC1 MRE11 NBN NCL NGFR OTUB1 PAXIP1 PBK PPP1CA PRKDC PTEN PTPA QARS1 RNF8 RPS6KA3 SMARCA4 SUPT5H TAF1C TAF5L TERF2 TIAM2 TOPORS TP53BP1 TRAF6 TSSK6 WRN 28 interacting genes: CASP8 CREBBP EPM2A H2AX HABP4 MTDH NKX3-1 SATB1 SERBP1 SIN3A SNIP1 SPOP SUMO1 SUMO2 TOP1 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2J1 UBE2L6 UBE2N UBE2W XRCC1
Entrez ID 3014 10210
HPRD ID 03465 11642
Ensembl ID ENSG00000188486 ENSG00000197579
Uniprot IDs P16104 Q9NS56
PDB IDs 1YDP 2AZM 2D31 2DYP 3SHV 3SQD 3SZM 3U3Z 6K1I 6K1J 6K1K
Enriched GO Terms of Interacting Partners?
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