H2AX and BRCA2

Number of citations of the paper that reports this interaction (PubMedID 20936109)
8

Data Source:
BioGRID (pull down)

		H2AX	BRCA2
Description		H2A.X variant histone	BRCA2 DNA repair associated
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleosome Condensed Nuclear Chromosome Male Germ Cell Nucleus XY Body Nucleus Nucleoplasm Replication Fork Centrosome Nuclear Speck Site Of Double-strand Break Extracellular Exosome Site Of DNA Damage	Chromosome, Telomeric Region Lateral Element Nucleus Nucleoplasm Centrosome Cytosol Secretory Granule Protein-containing Complex BRCA2-MAGE-D1 Complex
	Molecular Function	DNA Binding Damaged DNA Binding Protein Binding Enzyme Binding Histone Binding Protein Heterodimerization Activity	Protease Binding Single-stranded DNA Binding Histone Acetyltransferase Activity Protein Binding Protein C-terminus Binding H3 Histone Acetyltransferase Activity H4 Histone Acetyltransferase Activity Identical Protein Binding Gamma-tubulin Binding
	Biological Process	DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Nucleosome Assembly Cellular Response To DNA Damage Stimulus Spermatogenesis Response To Ionizing Radiation Cerebral Cortex Development Positive Regulation Of DNA Repair Meiotic Cell Cycle Cellular Response To Gamma Radiation Cellular Senescence	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination Oocyte Maturation Inner Cell Mass Cell Proliferation Nucleotide-excision Repair Double-strand Break Repair Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Male Meiosis I Spermatogenesis Brain Development Cell Aging Female Gonad Development Response To X-ray Response To UV-C Response To Gamma Radiation Hemopoiesis Regulation Of Cytokinesis Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Replication Fork Protection Centrosome Duplication Establishment Of Protein Localization To Telomere Mitotic Recombination-dependent Replication Fork Processing
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Amyloid fiber formation	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Meiotic recombination Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS			Apolipoprotein B levels ( 32203549) Basal cell carcinoma ( 31174203) Breast cancer ( 29059683 23535729 23535733) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol ( 24097068) LDL cholesterol levels ( 32203549 28334899) Lung cancer ( 28604730 24880342) Lung cancer in ever smokers ( 28604730) Small cell lung carcinoma ( 28604730) Squamous cell carcinoma ( 31174203) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		45 interacting genes: A2M ACTB ALG9 ATM ATR BARD1 BAZ1B BMI1 BRCA1 BRCA2 BRD1 CALM1 COPG1 DDX21 DHX9 EYA1 HUWE1 KAT5 MASP1 MDC1 MRE11 NBN NCL NGFR OTUB1 PAXIP1 PBK PPP1CA PRKDC PTEN PTPA QARS1 RNF8 RPS6KA3 SMARCA4 SUPT5H TAF1C TAF5L TERF2 TIAM2 TOPORS TP53BP1 TRAF6 TSSK6 WRN	49 interacting genes: ATM ATR BCCIP BRCA1 BUB1B CCNA1 CCNA2 CCND1 CCNE1 CDK1 CDK2 CFAP52 CHEK1 CHEK2 DMC1 DYNC1LI1 DYNC1LI2 EMSY ERCC5 FANCD2 FANCE FANCG FANCI FLNA H2AX HMG20B HNRNPC KAT2B LIMD1 MAGED1 NEDD4 PALB2 PDS5B PLEC PLK1 RAD51 RNASEH2A RPA1 SEM1 SERPINH1 SMAD3 STAT5A TP53 TP53BP1 UQCC1 USP11 USP21 WTIP XPO1
Entrez ID		3014	675
HPRD ID		03465	02554
Ensembl ID		ENSG00000188486	ENSG00000139618
Uniprot IDs		P16104	P51587
PDB IDs		1YDP 2AZM 2D31 2DYP 3SHV 3SQD 3SZM 3U3Z 6K1I 6K1J 6K1K	1N0W 3EU7 6GY2 6HQU
Enriched GO Terms of Interacting Partners?
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