ARAP3 and ARHGEF6

Number of citations of the paper that reports this interaction (PubMedID 17314030)
16

Data Source:
BioGRID (two hybrid)

		ARAP3	ARHGEF6
Description		ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	Rac/Cdc42 guanine nucleotide exchange factor 6
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytoskeleton Plasma Membrane Lamellipodium	Cytosol Lamellipodium
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Cytoskeleton Organization Signal Transduction Vesicle-mediated Transport Positive Regulation Of GTPase Activity	Apoptotic Process JNK Cascade Lamellipodium Assembly Regulation Of Catalytic Activity
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC3 GTPase cycle	NRAGE signals death through JNK G alpha (12/13) signalling events Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle
Drugs
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 26252872) Diffuse large B cell lymphoma ( 25261932) Fasting plasma glucose ( 32682390) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Household income ( 31844048) Lung cancer ( 28604730) Mean arterial pressure ( 27618448) Offspring birth weight ( 31043758)	Breast cancer ( 29059683)
Interacting Genes		10 interacting genes: ANKS1A ARHGEF6 CD2AP CLNK GGA3 INPPL1 PARD6B SAMHD1 SH3KBP1 TNKS2	38 interacting genes: ADAM15 ARAP3 ARHGEF7 BMPR1B CAPNS1 CBFA2T3 CCDC33 CDC42 CDK6 EPHB2 GIT1 GIT2 GOLGA2 GPRASP2 HSF2BP KRT27 NUTM1 PAK1 PAK2 PAK3 PARVB PNMA1 POU6F2 RWDD2A SH2D1A SH3GL3 SIRPA SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 TP53BP2 TRAF2 TRIM54 YWHAG ZNF580
Entrez ID		64411	9459
HPRD ID		09441	02226
Ensembl ID		ENSG00000120318	ENSG00000129675
Uniprot IDs		Q05CH1 Q8WWN8 Q9H7C1	B7Z3C7 Q15052 Q8N4Q3
PDB IDs		2KG5 2LNW 5JCP 5JD0 7A9B	1UJY 1WYR
Enriched GO Terms of Interacting Partners?
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