ARAP3 and INPPL1

Number of citations of the paper that reports this interaction (PubMedID 17314030)
16

Data Source:
BioGRID (pull down, pull down)

		ARAP3	INPPL1
Description		ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	inositol polyphosphate phosphatase like 1
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GO Annotations	Cellular Component	Ruffle Cytoplasm Cytoskeleton Plasma Membrane Lamellipodium	Nucleus Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Nuclear Speck Lamellipodium Filopodium
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding	Actin Binding Protein Binding SH3 Domain Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity SH2 Domain Binding
	Biological Process	Cytoskeleton Organization Signal Transduction Vesicle-mediated Transport Positive Regulation Of GTPase Activity	Endochondral Ossification Immune System Process Glucose Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Actin Filament Organization Cell Adhesion Negative Regulation Of Cell Population Proliferation Post-embryonic Development Negative Regulation Of Gene Expression Response To Insulin Phosphatidylinositol Dephosphorylation Ruffle Assembly
Pathways		RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC3 GTPase cycle	Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling
Drugs
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 26252872) Diffuse large B cell lymphoma ( 25261932) Fasting plasma glucose ( 32682390) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Household income ( 31844048) Lung cancer ( 28604730) Mean arterial pressure ( 27618448) Offspring birth weight ( 31043758)	Heart rate response to recovery post exercise (10 sec) ( 29497042)
Interacting Genes		10 interacting genes: ANKS1A ARHGEF6 CD2AP CLNK GGA3 INPPL1 PARD6B SAMHD1 SH3KBP1 TNKS2	24 interacting genes: ABL1 AR ARAP3 BCAR1 CBL CD4 CSF1R DRD2 EGFR ERBB2 ERBB3 ERBB4 FCGR2B FLNC GAB1 HID1 HYOU1 KMT2A MET SHC1 SORBS1 SORBS3 SRC UBC
Entrez ID		64411	3636
HPRD ID		09441	02900
Ensembl ID		ENSG00000120318	ENSG00000165458
Uniprot IDs		Q05CH1 Q8WWN8 Q9H7C1	O15357
PDB IDs		2KG5 2LNW 5JCP 5JD0 7A9B	2K4P 2KSO 2MK2 3NR8 4A9C 5OKM 5OKN 5OKO 5OKP 6SQU 6SRR
Enriched GO Terms of Interacting Partners?
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