AKTIP and TRIM32

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		AKTIP	TRIM32
Description		AKT interacting protein	tripartite motif containing 32
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane FHF Complex	Nucleus Cytoplasm Cytosol Striated Muscle Myosin Thick Filament
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity	Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Myosin Binding Tat Protein Binding Translation Initiation Factor Binding Identical Protein Binding Ubiquitin Binding Protein Self-association Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Apoptotic Process Cellular Response To DNA Damage Stimulus Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Positive Regulation Of Protein Binding Early Endosome To Late Endosome Transport Protein Localization To Perinuclear Region Of Cytoplasm	Protein Polyubiquitination Tissue Homeostasis Ubiquitin-dependent Protein Catabolic Process Actin Ubiquitination Response To UV Protein Ubiquitination Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Negative Regulation Of Viral Transcription Response To Tumor Necrosis Factor Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Positive Regulation Of Transcription, DNA-templated Muscle Cell Cellular Homeostasis Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Striated Muscle Cell Differentiation Axon Development Protein K48-linked Ubiquitination Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Interleukin-17-mediated Signaling Pathway Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Positive Regulation Of Cell Motility
Pathways			Regulation of innate immune responses to cytosolic DNA Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depressive symptoms (SSRI exposure interaction) ( 25649181) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip circumference adjusted for BMI ( 34021172 25673412) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Estimated glomerular filtration rate ( 31015462) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		35 interacting genes: ACTN2 AKT1 ASS1 CEP126 CTBP2 DMXL2 DZIP3 EXOC7 FHIP1B GTF3C1 HOOK1 HOOK2 HOOK3 IMMT IPO7 LMNA MAP3K7 MARCHF5 MATR3 NEB PDE4DIP PDPK1 POLA2 RASGRF2 RPA1 TRIM23 TRIM32 TRIM41 TWNK UPF2 UTP14A VPS16 VPS18 VPS41 ZNRF2	70 interacting genes: ABI2 AKTIP APOL1 ASIC4 ASTN2 ATP2B1 ATXN1 CLIP4 DERL1 ERGIC3 FADS6 GABARAP GABARAPL1 GABARAPL2 GEM GLIS2 GPR137B GSN HSPA4 ICMT IQCB1 IRAK1 KCTD9 LCN2 MAP1LC3A MAP1LC3B MAP1LC3C MID2 MOB1A MYCN NDRG2 NPAS3 NTAQ1 PDE9A PELI2 PIAS3 PIAS4 POLE3 PTCD2 PTPN11 RAB29 RABAC1 RNF208 RNF41 SCGB1A1 SDCBP STING1 SYT6 TCEANC TNC TOP1 TRIM23 TRIM27 TRIM5 TRIM72 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBE2V1 UBQLN1 UBQLN4 VPS11 XIAP
Entrez ID		64400	22954
HPRD ID		07467	03797
Ensembl ID		ENSG00000166971	ENSG00000119401
Uniprot IDs		A0A024R6S6 A0A024R6T5 Q9H8T0	A0A024R843 Q13049
PDB IDs			2CT2 5FEY
Enriched GO Terms of Interacting Partners?
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