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BLM and EXO1
Number of citations of the paper that reports this interaction (PubMedID
24705021
)
73
Data Source:
BioGRID
(affinity chromatography technology, pull down)
BLM
EXO1
Description
BLM RecQ like helicase
exonuclease 1
Image
GO Annotations
Cellular Component
Nuclear Chromosome
Chromosome, Telomeric Region
Lateral Element
Nucleus
Nucleoplasm
Replication Fork
Chromosome
Nucleolus
Cytoplasm
Cytosol
Nuclear Matrix
PML Body
Protein-containing Complex
Nucleus
Nucleoplasm
Plasma Membrane
Nuclear Body
Molecular Function
Four-way Junction DNA Binding
Y-form DNA Binding
Bubble DNA Binding
P53 Binding
DNA Binding
DNA Helicase Activity
Single-stranded DNA Binding
Helicase Activity
Protein Binding
ATP Binding
ATP-dependent Activity, Acting On DNA
Zinc Ion Binding
Four-way Junction Helicase Activity
ATP Hydrolysis Activity
Identical Protein Binding
Protein Homodimerization Activity
3'-5' DNA Helicase Activity
G-quadruplex DNA Binding
Forked DNA-dependent Helicase Activity
Telomeric D-loop Binding
Telomeric G-quadruplex DNA Binding
8-hydroxy-2'-deoxyguanosine DNA Binding
DNA/DNA Annealing Activity
DNA Binding
Chromatin Binding
RNA-DNA Hybrid Ribonuclease Activity
Exonuclease Activity
Protein Binding
5'-3' Exonuclease Activity
5'-flap Endonuclease Activity
5'-3' Exodeoxyribonuclease Activity
Single-stranded DNA 5'-3' Exodeoxyribonuclease Activity
Metal Ion Binding
Flap Endonuclease Activity
Double-stranded DNA 5'-3' Exodeoxyribonuclease Activity
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
DNA Replication
DNA Unwinding Involved In DNA Replication
DNA Repair
DNA Recombination
Cellular Response To DNA Damage Stimulus
Mitotic G2 DNA Damage Checkpoint Signaling
Response To X-ray
Replication Fork Processing
Telomere Maintenance Via Semi-conservative Replication
DNA Duplex Unwinding
G-quadruplex DNA Unwinding
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of DNA Recombination
Replication Fork Protection
Protein Complex Oligomerization
Protein Homooligomerization
Negative Regulation Of Cell Division
Telomeric D-loop Disassembly
Cellular Response To Ionizing Radiation
Cellular Response To Hydroxyurea
Cellular Response To Camptothecin
Regulation Of DNA-dependent DNA Replication
T-circle Formation
Humoral Immune Response Mediated By Circulating Immunoglobulin
DNA Repair
Mismatch Repair
DNA Recombination
Somatic Hypermutation Of Immunoglobulin Genes
Isotype Switching
Meiotic Cell Cycle
RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
T-circle Formation
Pathways
Processive synthesis on the C-strand of the telomere
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Meiotic recombination
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS
Coronary artery disease (
32469254
)
Daytime sleep phenotypes (
27126917
)
Basal cell carcinoma (
31174203
)
Breast cancer (
25751625
29059683
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Keratinocyte cancer (MTAG) (
31174203
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Menopause (age at onset) (
22267201
26414677
)
Interacting Genes
40 interacting genes:
ACAN
ATR
ATRX
BRIP1
CASP3
CHAF1A
CHEK1
DNA2
EXO1
FANCD2
FBXW7
FEN1
FES
JUN
MCRS1
MIB1
MLH1
MX1
NEK11
PSMD3
RAD51
RAD51D
RNF8
RPA1
SMC1A
SPIDR
SUMO1
SUMO2
SUMO3
SYN1
TERF1
TERF2
TOP3A
TOPBP1
TP53
TP53BP1
TRIM49
UBE2I
UPF2
WRN
21 interacting genes:
ATM
BLM
DCAF1
H4C1
KPNA4
KPNB1
MLH1
MLH3
MSH2
MSH3
PCNA
PMS2
SENP6
SFN
UBE2I
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
Entrez ID
641
9156
HPRD ID
05211
06932
Ensembl ID
ENSG00000197299
ENSG00000174371
Uniprot IDs
B7ZKN7
H0YNU5
P54132
A8K5H6
Q9UQ84
PDB IDs
2KV2
2MH9
2RRD
3WE2
3WE3
4CDG
4CGZ
4O3M
5LUP
5MK5
5U6K
7AUC
7AUD
3QE9
3QEA
3QEB
5UZV
5V04
5V05
5V06
5V07
5V08
5V09
5V0A
5V0B
5V0C
5V0D
5V0E
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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