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BLM and TERF2
Number of citations of the paper that reports this interaction (PubMedID
12181313
)
144
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, pull down)
HPRD
(in vitro, in vivo)
BLM
TERF2
Description
BLM RecQ like helicase
telomeric repeat binding factor 2
Image
GO Annotations
Cellular Component
Nuclear Chromosome
Chromosome, Telomeric Region
Lateral Element
Nucleus
Nucleoplasm
Replication Fork
Chromosome
Nucleolus
Cytoplasm
Cytosol
Nuclear Matrix
PML Body
Protein-containing Complex
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Nuclear Body
Shelterin Complex
Axon Cytoplasm
Molecular Function
Four-way Junction DNA Binding
Y-form DNA Binding
Bubble DNA Binding
P53 Binding
DNA Binding
DNA Helicase Activity
Single-stranded DNA Binding
Helicase Activity
Protein Binding
ATP Binding
ATP-dependent Activity, Acting On DNA
Zinc Ion Binding
Four-way Junction Helicase Activity
ATP Hydrolysis Activity
Identical Protein Binding
Protein Homodimerization Activity
3'-5' DNA Helicase Activity
G-quadruplex DNA Binding
Forked DNA-dependent Helicase Activity
Telomeric D-loop Binding
Telomeric G-quadruplex DNA Binding
8-hydroxy-2'-deoxyguanosine DNA Binding
DNA/DNA Annealing Activity
Double-stranded Telomeric DNA Binding
Telomerase Activity
Protein Binding
Protein C-terminus Binding
Enzyme Binding
Telomeric DNA Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
G-rich Strand Telomeric DNA Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
DNA Replication
DNA Unwinding Involved In DNA Replication
DNA Repair
DNA Recombination
Cellular Response To DNA Damage Stimulus
Mitotic G2 DNA Damage Checkpoint Signaling
Response To X-ray
Replication Fork Processing
Telomere Maintenance Via Semi-conservative Replication
DNA Duplex Unwinding
G-quadruplex DNA Unwinding
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of DNA Recombination
Replication Fork Protection
Protein Complex Oligomerization
Protein Homooligomerization
Negative Regulation Of Cell Division
Telomeric D-loop Disassembly
Cellular Response To Ionizing Radiation
Cellular Response To Hydroxyurea
Cellular Response To Camptothecin
Regulation Of DNA-dependent DNA Replication
T-circle Formation
Telomere Maintenance
In Utero Embryonic Development
RNA-dependent DNA Biosynthetic Process
Cell Cycle
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Telomere Capping
Telomeric Loop Formation
Protection From Non-homologous End Joining At Telomere
Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Recombination
Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Positive Regulation Of Nitric-oxide Synthase Activity
Telomeric D-loop Disassembly
Protein Localization To Chromosome, Telomeric Region
Cellular Senescence
Anterograde Axonal Transport Of Messenger Ribonucleoprotein Complex
Negative Regulation Of Beta-galactosidase Activity
Negative Regulation Of Telomere Single Strand Break Repair
Negative Regulation Of Telomere Capping
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of T-circle Formation
Negative Regulation Of Exonuclease Activity
Negative Regulation Of Telomeric D-loop Disassembly
Negative Regulation Of Cellular Senescence
Pathways
Processive synthesis on the C-strand of the telomere
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Meiotic recombination
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS
Coronary artery disease (
32469254
)
Daytime sleep phenotypes (
27126917
)
Body mass index (
26426971
)
Brain morphology (MOSTest) (
32665545
)
Daytime nap (
33568662
)
Leukocyte telomere length (
32109421
)
Logical memory (delayed recall) in normal cognition (
29274321
)
Pulse pressure (
30578418
)
Interacting Genes
40 interacting genes:
ACAN
ATR
ATRX
BRIP1
CASP3
CHAF1A
CHEK1
DNA2
EXO1
FANCD2
FBXW7
FEN1
FES
JUN
MCRS1
MIB1
MLH1
MX1
NEK11
PSMD3
RAD51
RAD51D
RNF8
RPA1
SMC1A
SPIDR
SUMO1
SUMO2
SUMO3
SYN1
TERF1
TERF2
TOP3A
TOPBP1
TP53
TP53BP1
TRIM49
UBE2I
UPF2
WRN
59 interacting genes:
AFAP1L2
ANXA5
APEX1
ASS1
ATM
BANP
BARD1
BLM
CCDC137
CTBP1
DDX21
DDX24
EP300
GNMT
H2AX
HDGFL2
HEXIM1
HEXIM2
HMGB1
HMGN1
HMGN2
HMGN3
HMGN4
LANCL2
LYAR
MAGOHB
NAIF1
NASP
NCL
NUMA1
NUMB
NUTF2
NXNL1
OCM2
ORC3
ORC6
PIAS1
PIK3R3
PPM1G
PRMT1
PTMA
RNF113A
RNF4
RPL13
RPRD1B
SET
SIAH1
SP100
SRSF6
TALDO1
TERF2IP
TINF2
TMSB10
TOR1AIP1
UBE2I
WDR4
WRN
XRCC6
ZC3H18
Entrez ID
641
7014
HPRD ID
05211
03610
Ensembl ID
ENSG00000197299
ENSG00000132604
Uniprot IDs
B7ZKN7
H0YNU5
P54132
Q15554
PDB IDs
2KV2
2MH9
2RRD
3WE2
3WE3
4CDG
4CGZ
4O3M
5LUP
5MK5
5U6K
7AUC
7AUD
1H6P
1VF9
1VFC
1W0U
1XG1
3BU8
3BUA
3K6G
3SJM
4M7C
4RQI
5WQD
5XYF
6J67
7C5D
Enriched GO Terms of Interacting Partners
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