EXO1 and MSH2

Number of citations of the paper that reports this interaction (PubMedID 9788596)
50

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		EXO1	MSH2
Description		exonuclease 1	mutS homolog 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Nuclear Body	Chromosome, Telomeric Region Nucleus Nucleoplasm Membrane Mismatch Repair Complex MutSalpha Complex MutSbeta Complex
	Molecular Function	DNA Binding Chromatin Binding RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity 5'-flap Endonuclease Activity 5'-3' Exodeoxyribonuclease Activity Single-stranded DNA 5'-3' Exodeoxyribonuclease Activity Metal Ion Binding Flap Endonuclease Activity Double-stranded DNA 5'-3' Exodeoxyribonuclease Activity	Magnesium Ion Binding Four-way Junction DNA Binding Double-strand/single-strand DNA Junction Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Protein C-terminus Binding ATP-dependent Activity, Acting On DNA Centromeric DNA Binding Enzyme Binding Protein Kinase Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Single Thymine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Protein Homodimerization Activity ADP Binding
	Biological Process	Humoral Immune Response Mediated By Circulating Immunoglobulin DNA Repair Mismatch Repair DNA Recombination Somatic Hypermutation Of Immunoglobulin Genes Isotype Switching Meiotic Cell Cycle RNA Phosphodiester Bond Hydrolysis, Endonucleolytic T-circle Formation	In Utero Embryonic Development Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Oxidative Phosphorylation DNA Repair Mismatch Repair Postreplication Repair Double-strand Break Repair DNA Recombination Germ Cell Development Determination Of Adult Lifespan Male Gonad Development Response To X-ray Response To UV-B Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments B Cell Mediated Immunity B Cell Differentiation Mitotic Intra-S DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Neuron Apoptotic Process Maintenance Of DNA Repeat Elements Isotype Switching Negative Regulation Of DNA Recombination Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Helicase Activity Protein Localization To Chromatin
Pathways		Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2 Defective Mismatch Repair Associated With MSH6 TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases
GWAS		Basal cell carcinoma ( 31174203) Breast cancer ( 25751625 29059683) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Keratinocyte cancer (MTAG) ( 31174203) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Menopause (age at onset) ( 22267201 26414677)	Electroencephalogram traits ( 25387704) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		21 interacting genes: ATM BLM DCAF1 H4C1 KPNA4 KPNB1 MLH1 MLH3 MSH2 MSH3 PCNA PMS2 SENP6 SFN UBE2I YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	49 interacting genes: AKT1 ALK ANXA7 APPBP2 ATR BARD1 BRCA1 CCDC180 CDC14B CDC42 CDKN1A CHEK2 CREBBP DVL1 EPHA2 ESR1 ESR2 EXO1 FBP1 FBP2 FGFR4 GALNT12 GRB7 HDAC6 HRAS HUS1 LEF1 MAX MSH3 MSH6 MYC PCNA PPP3R2 RAD1 RAD9A RPA4 RPP14 SMAD1 SMC1A SMN1 STX17 SUMO2 TDRD7 TK1 TREX1 TRIM29 USP10 XPA ZNF510
Entrez ID		9156	4436
HPRD ID		06932	00389
Ensembl ID		ENSG00000174371	ENSG00000095002
Uniprot IDs		A8K5H6 Q9UQ84	A0A2R8Y6P0 P43246
PDB IDs		3QE9 3QEA 3QEB 5UZV 5V04 5V05 5V06 5V07 5V08 5V09 5V0A 5V0B 5V0C 5V0D 5V0E	2O8B 2O8C 2O8D 2O8E 2O8F 3THW 3THX 3THY 3THZ
Enriched GO Terms of Interacting Partners?
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