XPNPEP3 and CYB5R3

		XPNPEP3	CYB5R3
Description		X-prolyl aminopeptidase 3	cytochrome b5 reductase 3
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Hemoglobin Complex Membrane Azurophil Granule Lumen Nitric-oxide Synthase Complex
	Molecular Function	Aminopeptidase Activity Protein Binding Peptidase Activity Manganese Ion Binding Protein Homodimerization Activity Metalloaminopeptidase Activity	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding AMP Binding ADP Binding Nitrite Reductase (NO-forming) Activity NAD Binding FAD Binding
	Biological Process	Glomerular Filtration Proteolysis Protein Processing	Cholesterol Biosynthetic Process Nitric Oxide Biosynthetic Process Blood Circulation
Pathways			Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation
Drugs			NADH Flavin adenine dinucleotide Copper
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) C-reactive protein levels ( 30388399) Experiencing mood swings ( 29500382) Low density lipoprotein cholesterol levels ( 32154731) Refractive error ( 32231278) Schizophrenia ( 28991256)	Initial pursuit acceleration ( 29064472)
Interacting Genes		2 interacting genes: CYB5R3 L3MBTL2	68 interacting genes: ADAM33 AGTRAP AIG1 ALG8 AQP6 ARSA ASGR1 BNIP2 CDIPT CERS4 CNIH1 COL8A2 CSGALNACT2 CYB5A CYCS ELOVL4 FAM210B FAM3C FAXDC2 FUNDC2 FXYD3 GAS1 GAST GPR152 GRM2 HBG2 HSD17B13 L3MBTL2 LAPTM5 LRCH4 MFSD6 NINJ1 NRM NSG1 NXPE3 ORMDL2 PNLIPRP1 REEP4 RPS6KB1 SBF1 SLC10A1 SLC10A6 SLC13A3 SLC22A2 SLC35A4 SLC35B2 SLC38A7 SPP1 STOM TMEM115 TMEM14B TMEM14C TMEM201 TMEM31 TMEM51 TMEM60 TMEM79 TNF TNFRSF10C TUBGCP6 UBIAD1 VAMP1 VAMP4 VAMP5 VMP1 WFDC2 XPNPEP3 ZDHHC15
Entrez ID		63929	1727
HPRD ID		10052	08942
Ensembl ID		ENSG00000196236	ENSG00000100243
Uniprot IDs		A0A087X0Z2 Q9NQH7	P00387
PDB IDs		5X49	1M91 1UMK
Enriched GO Terms of Interacting Partners?
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