CYB5R3 and XPNPEP3

		CYB5R3	XPNPEP3
Description		cytochrome b5 reductase 3	X-prolyl aminopeptidase 3
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Hemoglobin Complex Membrane Azurophil Granule Lumen Nitric-oxide Synthase Complex	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding AMP Binding ADP Binding Nitrite Reductase (NO-forming) Activity NAD Binding FAD Binding	Aminopeptidase Activity Protein Binding Peptidase Activity Manganese Ion Binding Protein Homodimerization Activity Metalloaminopeptidase Activity
	Biological Process	Cholesterol Biosynthetic Process Nitric Oxide Biosynthetic Process Blood Circulation	Glomerular Filtration Proteolysis Protein Processing
Pathways		Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation
Drugs		NADH Flavin adenine dinucleotide Copper
Diseases
GWAS		Initial pursuit acceleration ( 29064472)	Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) C-reactive protein levels ( 30388399) Experiencing mood swings ( 29500382) Low density lipoprotein cholesterol levels ( 32154731) Refractive error ( 32231278) Schizophrenia ( 28991256)
Interacting Genes		68 interacting genes: ADAM33 AGTRAP AIG1 ALG8 AQP6 ARSA ASGR1 BNIP2 CDIPT CERS4 CNIH1 COL8A2 CSGALNACT2 CYB5A CYCS ELOVL4 FAM210B FAM3C FAXDC2 FUNDC2 FXYD3 GAS1 GAST GPR152 GRM2 HBG2 HSD17B13 L3MBTL2 LAPTM5 LRCH4 MFSD6 NINJ1 NRM NSG1 NXPE3 ORMDL2 PNLIPRP1 REEP4 RPS6KB1 SBF1 SLC10A1 SLC10A6 SLC13A3 SLC22A2 SLC35A4 SLC35B2 SLC38A7 SPP1 STOM TMEM115 TMEM14B TMEM14C TMEM201 TMEM31 TMEM51 TMEM60 TMEM79 TNF TNFRSF10C TUBGCP6 UBIAD1 VAMP1 VAMP4 VAMP5 VMP1 WFDC2 XPNPEP3 ZDHHC15	2 interacting genes: CYB5R3 L3MBTL2
Entrez ID		1727	63929
HPRD ID		08942	10052
Ensembl ID		ENSG00000100243	ENSG00000196236
Uniprot IDs		P00387	A0A087X0Z2 Q9NQH7
PDB IDs		1M91 1UMK	5X49
Enriched GO Terms of Interacting Partners?
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