SDF2 and CCL8

		SDF2	CCL8
Description		stromal cell derived factor 2	C-C motif chemokine ligand 8
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Chaperone Complex	Extracellular Space
	Molecular Function	Misfolded Protein Binding	Protein Kinase Activity Protein Binding Chemokine Activity Heparin Binding Phospholipase Activator Activity CCR Chemokine Receptor Binding
	Biological Process	Chaperone Cofactor-dependent Protein Refolding	Monocyte Chemotaxis Positive Regulation Of Leukocyte Migration Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Negative Regulation By Host Of Viral Genome Replication Eosinophil Chemotaxis Lymphocyte Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Proliferation Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor
Pathways
Drugs		Malonate Ion	Pidolic acid
Diseases
GWAS			Blood protein levels ( 30072576 29875488 28240269) Crohn's disease ( 22412388) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		7 interacting genes: CCL15 CCL16 CCL8 HNRNPD HSPB2 UBC ZNF18	21 interacting genes: ACKR1 ACKR2 ACKR4 CCL11 CCL13 CCL2 CCL26 CCR1 CCR3 CCR5 CXCL10 CXCL11 CXCL17 CXCL2 CXCL6 CXCL8 MMP3 PPBP SDF2 VCAN XCL2
Entrez ID		6388	6355
HPRD ID		04243	03791
Ensembl ID		ENSG00000132581	ENSG00000108700
Uniprot IDs		Q6IBU4 Q99470	P80075
PDB IDs			1ESR
Enriched GO Terms of Interacting Partners?
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