CCL8 and CXCL10

Number of citations of the paper that reports this interaction (PubMedID 28381538)
37

Data Source:
BioGRID (pull down)

		CCL8	CXCL10
Description		C-C motif chemokine ligand 8	C-X-C motif chemokine ligand 10
Image
GO Annotations	Cellular Component	Extracellular Space	Extracellular Region Extracellular Space External Side Of Plasma Membrane
	Molecular Function	Protein Kinase Activity Protein Binding Chemokine Activity Heparin Binding Phospholipase Activator Activity CCR Chemokine Receptor Binding	Signaling Receptor Binding Protein Binding Chemokine Activity Heparin Binding CAMP-dependent Protein Kinase Regulator Activity Chemoattractant Activity CXCR Chemokine Receptor Binding CXCR3 Chemokine Receptor Binding
	Biological Process	Monocyte Chemotaxis Positive Regulation Of Leukocyte Migration Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Negative Regulation By Host Of Viral Genome Replication Eosinophil Chemotaxis Lymphocyte Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Proliferation Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor	Chemotaxis Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Muscle Organ Development Blood Circulation Positive Regulation Of Cell Population Proliferation Response To Cold Response To Gamma Radiation T Cell Chemotaxis Regulation Of T Cell Chemotaxis Response To Auditory Stimulus Negative Regulation Of Angiogenesis Neutrophil Chemotaxis Response To Vitamin D Cellular Response To Heat Endothelial Cell Activation Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Catalytic Activity Positive Chemotaxis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotaxis Cellular Response To Virus Antiviral Innate Immune Response Regulation Of Endothelial Tube Morphogenesis Negative Regulation Of Myoblast Fusion Positive Regulation Of T Cell Migration
Pathways			Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs		Pidolic acid	N-Methylleucine Eldelumab Clove oil
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Crohn's disease ( 22412388) Triglyceride levels in HIV infection ( 33109212)	Blood protein levels ( 30072576 29875488 28240269) C-X-C motif chemokine 10 levels ( 25147954) Hippocampal volume ( 29274321) Interferon gamma-induced protein 10 levels ( 27989323 31217265) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		21 interacting genes: ACKR1 ACKR2 ACKR4 CCL11 CCL13 CCL2 CCL26 CCR1 CCR3 CCR5 CXCL10 CXCL11 CXCL17 CXCL2 CXCL6 CXCL8 MMP3 PPBP SDF2 VCAN XCL2	22 interacting genes: CCL11 CCL13 CCL21 CCL26 CCL28 CCL5 CCL8 CCR3 CXCL11 CXCL12 CXCL14 CXCL17 CXCL6 CXCL9 CXCR3 DPP4 IGFBP7 PF4 PF4V1 PPBP VCAN XCL1
Entrez ID		6355	3627
HPRD ID		03791	00930
Ensembl ID		ENSG00000108700	ENSG00000169245
Uniprot IDs		P80075	P02778
PDB IDs		1ESR	1LV9 1O7Y 1O7Z 1O80
Enriched GO Terms of Interacting Partners?
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