CCL8 and XCL2

Number of citations of the paper that reports this interaction (PubMedID 28381538)
37

Data Source:
BioGRID (pull down)

		CCL8	XCL2
Description		C-C motif chemokine ligand 8	X-C motif chemokine ligand 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Protein Kinase Activity Protein Binding Chemokine Activity Heparin Binding Phospholipase Activator Activity CCR Chemokine Receptor Binding	Protein Binding Chemokine Activity CCR Chemokine Receptor Binding
	Biological Process	Monocyte Chemotaxis Positive Regulation Of Leukocyte Migration Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Negative Regulation By Host Of Viral Genome Replication Eosinophil Chemotaxis Lymphocyte Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Proliferation Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor	Monocyte Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Blood Circulation Positive Regulation Of T Cell Chemotaxis Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Lymphocyte Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor
Pathways			Chemokine receptors bind chemokines G alpha (q) signalling events
Drugs		Pidolic acid
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Crohn's disease ( 22412388) Triglyceride levels in HIV infection ( 33109212)	Emphysema imaging phenotypes ( 26030696) Lung cancer ( 28604730) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		21 interacting genes: ACKR1 ACKR2 ACKR4 CCL11 CCL13 CCL2 CCL26 CCR1 CCR3 CCR5 CXCL10 CXCL11 CXCL17 CXCL2 CXCL6 CXCL8 MMP3 PPBP SDF2 VCAN XCL2	19 interacting genes: CCL2 CCL20 CCL21 CCL26 CCL28 CCL5 CCL7 CCL8 CXCL12 CXCL17 CXCL2 CXCL3 CXCL5 KRTAP1-3 KRTAP10-9 NOTCH2NLA PF4 PF4V1 XCR1
Entrez ID		6355	6846
HPRD ID		03791	05317
Ensembl ID		ENSG00000108700	ENSG00000143185
Uniprot IDs		P80075	Q9UBD3
PDB IDs		1ESR
Enriched GO Terms of Interacting Partners?
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