CCL17 and CCR4

Number of citations of the paper that reports this interaction (PubMedID 9169480)
115

Data Source:
HPRD (in vivo, in vitro)

		CCL17	CCR4
Description		C-C motif chemokine ligand 17	C-C motif chemokine receptor 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Neuronal Cell Body
	Molecular Function	Signaling Receptor Binding Protein Binding Chemokine Activity CCR4 Chemokine Receptor Binding CCR Chemokine Receptor Binding	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Monocyte Chemotaxis Chemotaxis Inflammatory Response G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Multicellular Organism Development Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Negative Regulation Of Myoblast Differentiation Lymphocyte Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor	Neuron Migration Tolerance Induction Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Radiation Response To Bacterium Calcium-mediated Signaling Response To Antibiotic Homeostasis Of Number Of Cells Positive Regulation Of Positive Chemotaxis Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs			Mogamulizumab FLX475
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Thymus and reactivation regulated chemokine levels ( 33227023)	Asthma ( 31959851) Celiac disease ( 22057235 20190752) Multiple sclerosis ( 24076602) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (perceptual aberration scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised physical anhedonia scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised social anhedonia scale) ( 28525603)
Interacting Genes		9 interacting genes: ACKR1 CCL21 CCL25 CCL26 CCL28 CCL5 CCR4 CCR8 VCAM1	37 interacting genes: ATP2A2 B3GAT3 BSG CACNA1H CCKBR CCL17 CCL22 CCL3 CCL5 CDK10 CH25H CLASP2 CLPTM1 CNTNAP1 DHCR24 ERGIC3 FAM234A FXR2 GHITM GRK2 GRK3 NAT14 NDRG2 NSUN2 PKM PRDX1 PTOV1 RTN1 RTN4 SLC12A5 SLC3A2 SLCO4A1 STIMATE SYNGR2 TMEM101 TMEM11 TRARG1
Entrez ID		6361	1233
HPRD ID		03309	05324
Ensembl ID		ENSG00000102970	ENSG00000183813
Uniprot IDs		Q92583	A0N0Q1 P51679
PDB IDs		1NR2 1NR4 5WK3
Enriched GO Terms of Interacting Partners?
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