CCL2 and MMP8

Number of citations of the paper that reports this interaction (PubMedID 12149192)
178

Data Source:
HPRD (in vivo, in vitro)

		CCL2	MMP8
Description		C-C motif chemokine ligand 2	matrix metallopeptidase 8
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Specific Granule Lumen Collagen-containing Extracellular Matrix Tertiary Granule Lumen
	Molecular Function	Protein Kinase Activity Signaling Receptor Binding Protein Binding Chemokine Activity CCR2 Chemokine Receptor Binding CCR Chemokine Receptor Binding	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Zinc Ion Binding
	Biological Process	MAPK Cascade Angiogenesis Monocyte Chemotaxis Protein Phosphorylation Chemotaxis Inflammatory Response Humoral Immune Response Cytoskeleton Organization Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Shape Response To Bacterium Animal Organ Morphogenesis Viral Genome Replication Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Cellular Homeostasis Neutrophil Chemotaxis Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Helper T Cell Extravasation Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Astrocyte Cell Migration Cellular Response To Fibroblast Growth Factor Stimulus Eosinophil Chemotaxis Macrophage Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of T Cell Activation Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Synaptic Transmission, Glutamatergic Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Positive Regulation Of Calcium Ion Import Positive Regulation Of NMDA Glutamate Receptor Activity Negative Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Apoptotic Cell Clearance Negative Regulation Of Natural Killer Cell Chemotaxis	Proteolysis Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Endodermal Cell Differentiation Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of JNK Cascade Regulation Of Neuroinflammatory Response Positive Regulation Of Neuroinflammatory Response Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Microglial Cell Activation Positive Regulation Of Microglial Cell Activation
Pathways		Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling	Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Neutrophil degranulation
Drugs		Mimosine Danazol Chondroitin sulfate	Marimastat 1-Hydroxyamine-2-Isobutylmalonic Acid 2-Thiomethyl-3-Phenylpropanoic Acid 2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid 5-[4-(2-Hydroxyethyl)-1-piperidinyl]-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione Glycinamide Batimastat N-{2-[(4'-CYANO-1,1'-BIPHENYL-4-YL)OXY]ETHYL}-N'-HYDROXY-N-METHYLUREA (5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)methyl]-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidine-2-carboxamide (1S)-1-{[(4'-methoxy-1,1'-biphenyl-4-yl)sulfonyl]amino}-2-methylpropylphosphonic acid (1R)-1-{[(4'-methoxy-1,1'-biphenyl-4-yl)sulfonyl]amino}-2-methylpropylphosphonic acid 3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACID HYDROXYAMIDE BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHYDRO-[1,3,4]THIADIAZIN-2-YLIDENE]-AMINE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID 3-AMINO-AZACYCLOTRIDECAN-2-ONE
Diseases
GWAS		Crohn's disease ( 28067908 22412388 21102463) Gut microbiota (functional units) ( 27694959) Hypothyroidism ( 22493691) Inflammatory bowel disease ( 28067908 23128233)	Blood protein levels ( 30072576) Epilepsy ( 25087078) Prostate cancer ( 23535732)
Interacting Genes		28 interacting genes: ACKR1 ACKR2 ACKR4 CCL11 CCL13 CCL15 CCL26 CCL4L1 CCL5 CCL8 CCR1 CCR10 CCR3 CCR5 CXCL17 CXCL8 CXCL9 MMP1 MMP3 MMP8 PF4 RNF4 SLC16A2 SLC22A1 SLC22A2 TMX2 VCAN XCL2	7 interacting genes: ACAN BCAN CCL2 FBXO7 TFPI TIMP2 UMOD
Entrez ID		6347	4317
HPRD ID		01149	00385
Ensembl ID		ENSG00000108691	ENSG00000118113
Uniprot IDs		P13500	B4E0I2 P22894
PDB IDs		1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9	1A85 1A86 1BZS 1I73 1I76 1JAN 1JAO 1JAP 1JAQ 1JH1 1JJ9 1KBC 1MMB 1MNC 1ZP5 1ZS0 1ZVX 2OY2 2OY4 3DNG 3DPE 3DPF 3TT4 4QKZ 5H8X
Enriched GO Terms of Interacting Partners?
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