CCL2 and CCL4L1

Number of citations of the paper that reports this interaction (PubMedID 28381538)
37

Data Source:
BioGRID (pull down)

		CCL2	CCL4L1
Description		C-C motif chemokine ligand 2	C-C motif chemokine ligand 4 like 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Space
	Molecular Function	Protein Kinase Activity Signaling Receptor Binding Protein Binding Chemokine Activity CCR2 Chemokine Receptor Binding CCR Chemokine Receptor Binding	Protein Binding Chemokine Activity CCR Chemokine Receptor Binding
	Biological Process	MAPK Cascade Angiogenesis Monocyte Chemotaxis Protein Phosphorylation Chemotaxis Inflammatory Response Humoral Immune Response Cytoskeleton Organization Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Shape Response To Bacterium Animal Organ Morphogenesis Viral Genome Replication Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Cellular Homeostasis Neutrophil Chemotaxis Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Helper T Cell Extravasation Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Astrocyte Cell Migration Cellular Response To Fibroblast Growth Factor Stimulus Eosinophil Chemotaxis Macrophage Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of T Cell Activation Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Synaptic Transmission, Glutamatergic Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Positive Regulation Of Calcium Ion Import Positive Regulation Of NMDA Glutamate Receptor Activity Negative Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Apoptotic Cell Clearance Negative Regulation Of Natural Killer Cell Chemotaxis	Monocyte Chemotaxis Inflammatory Response G Protein-coupled Receptor Signaling Pathway Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Eosinophil Chemotaxis Lymphocyte Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor
Pathways		Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling G alpha (i) signalling events
Drugs		Mimosine Danazol Chondroitin sulfate
Diseases
GWAS		Crohn's disease ( 28067908 22412388 21102463) Gut microbiota (functional units) ( 27694959) Hypothyroidism ( 22493691) Inflammatory bowel disease ( 28067908 23128233)	Body mass index ( 26426971) Macrophage inflammatory protein 1b levels ( 27989323)
Interacting Genes		28 interacting genes: ACKR1 ACKR2 ACKR4 CCL11 CCL13 CCL15 CCL26 CCL4L1 CCL5 CCL8 CCR1 CCR10 CCR3 CCR5 CXCL17 CXCL8 CXCL9 MMP1 MMP3 MMP8 PF4 RNF4 SLC16A2 SLC22A1 SLC22A2 TMX2 VCAN XCL2	3 interacting genes: CCL2 CXCL13 PF4V1
Entrez ID		6347	388372
HPRD ID		01149	16689
Ensembl ID		ENSG00000108691
Uniprot IDs		P13500	B7ZW36 P13236 Q8NHW4
PDB IDs		1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9	1HUM 1HUN 1JE4 2FFK 2FIN 2X6L 3TN2 4RAL
Enriched GO Terms of Interacting Partners?
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