MMP8 and ACAN

Number of citations of the paper that reports this interaction (PubMedID 8216228)
33

Data Source:
HPRD (in vitro)

		MMP8	ACAN
Description		matrix metallopeptidase 8	aggrecan
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Specific Granule Lumen Collagen-containing Extracellular Matrix Tertiary Granule Lumen	Extracellular Region Golgi Lumen Extracellular Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Zinc Ion Binding	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding Metal Ion Binding
	Biological Process	Proteolysis Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Endodermal Cell Differentiation Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of JNK Cascade Regulation Of Neuroinflammatory Response Positive Regulation Of Neuroinflammatory Response Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Microglial Cell Activation Positive Regulation Of Microglial Cell Activation	Skeletal System Development Proteolysis Cell Adhesion Central Nervous System Development
Pathways		Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Neutrophil degranulation	Degradation of the extracellular matrix Degradation of the extracellular matrix Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Drugs		Marimastat 1-Hydroxyamine-2-Isobutylmalonic Acid 2-Thiomethyl-3-Phenylpropanoic Acid 2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid 5-[4-(2-Hydroxyethyl)-1-piperidinyl]-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione Glycinamide Batimastat N-{2-[(4'-CYANO-1,1'-BIPHENYL-4-YL)OXY]ETHYL}-N'-HYDROXY-N-METHYLUREA (5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)methyl]-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidine-2-carboxamide (1S)-1-{[(4'-methoxy-1,1'-biphenyl-4-yl)sulfonyl]amino}-2-methylpropylphosphonic acid (1R)-1-{[(4'-methoxy-1,1'-biphenyl-4-yl)sulfonyl]amino}-2-methylpropylphosphonic acid 3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACID HYDROXYAMIDE BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHYDRO-[1,3,4]THIADIAZIN-2-YLIDENE]-AMINE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID 3-AMINO-AZACYCLOTRIDECAN-2-ONE	Ilomastat
Diseases
GWAS		Blood protein levels ( 30072576) Epilepsy ( 25087078) Prostate cancer ( 23535732)	Age-related hearing impairment ( 27764096) Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Dupuytren's disease ( 28886342) Height ( 21998595 28552196 20881960 25282103 25133637 25429064 23563607 31562340 28270201 18391952 33713608) Hip circumference adjusted for BMI ( 34021172 25673412) Infant length ( 25281659) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500)
Interacting Genes		7 interacting genes: ACAN BCAN CCL2 FBXO7 TFPI TIMP2 UMOD	23 interacting genes: ADAMTS1 ADAMTS4 ADAMTS5 BLM CTSB FBLN1 FBLN2 HAPLN1 IDH2 LUM MAN2A2 MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 PTPRF SLCO3A1 STARD5 TNFAIP6 TNR
Entrez ID		4317	176
HPRD ID		00385	01123
Ensembl ID		ENSG00000118113	ENSG00000157766
Uniprot IDs		B4E0I2 P22894	A0A5K1VW97 P16112
PDB IDs		1A85 1A86 1BZS 1I73 1I76 1JAN 1JAO 1JAP 1JAQ 1JH1 1JJ9 1KBC 1MMB 1MNC 1ZP5 1ZS0 1ZVX 2OY2 2OY4 3DNG 3DPE 3DPF 3TT4 4QKZ 5H8X	4MD4
Enriched GO Terms of Interacting Partners?
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