ELAC2 and CUX1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ELAC2	CUX1
Description		elaC ribonuclease Z 2	cut like homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial Nucleoid	Golgi Membrane Chromatin Nucleus Nucleoplasm Golgi Apparatus Cytosol
	Molecular Function	RNA Binding Endoribonuclease Activity TRNA-specific Ribonuclease Activity 3'-tRNA Processing Endoribonuclease Activity Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein-macromolecule Adaptor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	TRNA Catabolic Process TRNA 3'-end Processing Mitochondrial TRNA 3'-trailer Cleavage, Endonucleolytic Mitochondrial TRNA Processing	Negative Regulation Of Transcription By RNA Polymerase II Retrograde Transport, Vesicle Recycling Within Golgi Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Positive Regulation Of Dendrite Morphogenesis
Pathways		tRNA processing in the nucleus tRNA processing in the mitochondrion rRNA processing in the mitochondrion tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Intra-Golgi traffic
Drugs
Diseases
GWAS		Squamous cell lung carcinoma ( 28604730)	Attention deficit hyperactivity disorder symptom score ( 27663945) Basal cell carcinoma ( 31174203 33549134 27539887) Breast cancer ( 29059683) Cerebellum cortex volume ( 31530798) Chronotype ( 30696823) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Keratinocyte cancer (MTAG) ( 31174203) Mean platelet volume ( 32888494 27863252) Morning person ( 30696823) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Response to antidepressants ( 22584459) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		11 interacting genes: ASCC2 CTBP1 CTBP2 CUX1 DRC3 GID4 GOLM1 NDUFA7 RING1 SMAD2 SUMO2	21 interacting genes: BIN1 CA12 CCNA1 CDC25A CDK1 CDK7 CREBBP CTSL CYTH2 EHMT2 ELAC2 GOLGA5 HMGB1 KAT2B MAX RB1 RECQL5 SATB1 SDC3 SUMO2 TLE4
Entrez ID		60528	1523
HPRD ID		05641	00295
Ensembl ID		ENSG00000006744	ENSG00000257923
Uniprot IDs		A0A0S2Z5M8 Q9BQ52	P39880 Q13948 Q3LIA3
PDB IDs
Enriched GO Terms of Interacting Partners?
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