HPSE2 and TLL2

		HPSE2	TLL2
Description		heparanase 2 (inactive)	tolloid like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Extracellular Matrix	Extracellular Region
	Molecular Function	Heparanase Activity Heparan Sulfate Proteoglycan Binding	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	Glycosaminoglycan Catabolic Process Biological_process Positive Regulation Of Cell Population Proliferation Extracellular Matrix Organization	Proteolysis Cell Differentiation Collagen Fibril Organization Negative Regulation Of Skeletal Muscle Tissue Growth
Pathways		HS-GAG degradation	Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils
Drugs			Methyl N-{[(1R)-1-({1-[(benzyloxy)carbonyl]-L-prolyl-6-ammonio-L-norleucyl}amino)-2-phenylethyl](hydroxy)phosphoryl}-L-alanyl-L-prolinate
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Asthma (childhood onset) ( 23829686) Migraine ( 27322543) Obesity-related traits ( 23251661) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482)	Attention deficit hyperactivity disorder ( 18839057) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Platelet reactivity in response to clopidogrel treatment ( 32472697) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770)
Interacting Genes		1 interacting genes: TLL2	5 interacting genes: DNTT HPSE2 PAPSS2 PPP1R3C RBP4
Entrez ID		60495	7093
HPRD ID		13669	05993
Ensembl ID		ENSG00000172987	ENSG00000095587
Uniprot IDs		Q2M1H9 Q8WWQ2	Q9Y6L7
PDB IDs
Enriched GO Terms of Interacting Partners?
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