RNASEL and TCF12

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		RNASEL	TCF12
Description		ribonuclease L	transcription factor 12
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GO Annotations	Cellular Component	Cellular_component Mitochondrial Matrix Cytosol Nuclear Matrix	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck Intracellular Membrane-bounded Organelle RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Binding Endoribonuclease Activity Ribonuclease Activity Protein Kinase Activity Protein Binding ATP Binding RRNA Binding Ribonucleoprotein Complex Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding CAMP Response Element Binding BHLH Transcription Factor Binding SMAD Binding Protein Heterodimerization Activity E-box Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	RRNA Processing RNA Processing MRNA Processing Protein Phosphorylation Regulation Of MRNA Stability Negative Regulation Of Viral Genome Replication Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glucose Import Defense Response To Virus RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Regulation Of Transcription By RNA Polymerase II Immune Response Nervous System Development Muscle Organ Development Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		OAS antiviral response Interferon alpha/beta signaling	Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs NGF-stimulated transcription NGF-stimulated transcription
Drugs
Diseases
GWAS		Morning vs. evening chronotype ( 26835600) Multiple sclerosis ( 23412934)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein B levels ( 32203549) Body mass index ( 28892062) Glaucoma (primary open-angle) ( 33627673 29891935) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Male-pattern baldness ( 28196072) Mean platelet volume ( 32888494 27863252) Triglyceride levels ( 32154731) Type 2 diabetes ( 30297969)
Interacting Genes		3 interacting genes: ABCE1 AR TCF12	86 interacting genes: ACTB ADAM10 ARL16 ARMC8 ASCL3 ASCL4 BCL2L10 BMERB1 BMF C1orf109 CDKN2C CFAP206 CKS1B CLCNKA CRCP CREBBP DDX6 DGCR6 EDRF1 EP300 EXOC8 FERD3L FIGLA FRMD6 GRB7 HAND1 HAND2 HEXIM2 HOPX ID1 ID2 ID3 LAMTOR5 LNX1 LYSMD1 MAPK6 MAPKBP1 MLLT6 MORN4 MSC MSGN1 MYF6 MYO15B NAGK NEK6 NEUROD1 NEUROG1 NEUROG3 NGLY1 NHLH2 OLIG3 OSGIN1 PIN1 PRKAB2 PRSS23 PSMA1 PTF1A QARS1 RBM8A RNASEL RSL24D1 RUNX1T1 SCG3 SLC12A1 SLC24A1 SOX10 SOX8 SPG21 SPTBN5 SRI STAT5A STK16 TAF4 TAL2 TBC1D21 TBP TCF21 TCF23 TCF3 TRIM72 TSNAX TWIST2 VPS28 WTAP YKT6 ZNF688
Entrez ID		6041	6938
HPRD ID		01590	02725
Ensembl ID		ENSG00000135828	ENSG00000140262
Uniprot IDs		Q05823	A0A024R5T1 A0A024R5Z0 F5GY10 Q99081
PDB IDs		1WDY 4G8K 4G8L 4OAU 4OAV	2KNH 4JOL
Enriched GO Terms of Interacting Partners?
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