BCL6 and HDAC9

Number of citations of the paper that reports this interaction (PubMedID 12590135)
53

Data Source:
HPRD (in vivo, in vitro)

		BCL6	HDAC9
Description		BCL6 transcription repressor	histone deacetylase 9
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Nucleolus Golgi Apparatus	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Histone Methyltransferase Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Activity (H4-K16 Specific) Histone Deacetylase Binding Metal Ion Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Regulation Of Cytokine Production Negative Regulation Of Cell-matrix Adhesion Germinal Center Formation Regulation Of Germinal Center Formation Regulation Of Immune System Process Negative Regulation Of B Cell Apoptotic Process Regulation Of Transcription By RNA Polymerase II Inflammatory Response Cellular Response To DNA Damage Stimulus Rho Protein Signal Transduction Spermatogenesis Protein Localization Negative Regulation Of Cell Population Proliferation Actin Cytoskeleton Organization B Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Histone Deacetylation Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Rho Protein Signal Transduction Type 2 Immune Response Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Regulation Of Memory T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Isotype Switching To IgE Isotypes Erythrocyte Development Regulation Of Inflammatory Response Regulation Of Immune Response Positive Regulation Of Cellular Component Movement Negative Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of Cellular Senescence	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cytokine Production Response To Amphetamine Inflammatory Response Heart Development Histone Deacetylation Neuron Differentiation B Cell Differentiation Cellular Response To Insulin Stimulus Peptidyl-lysine Deacetylation B Cell Activation Cholesterol Homeostasis Negative Regulation Of Transcription, DNA-templated Regulation Of Skeletal Muscle Fiber Development Negative Regulation Of Lipoprotein Lipase Activity Regulation Of Striated Muscle Cell Differentiation Histone H3 Deacetylation Histone H4 Deacetylation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Histone H4-K16 Deacetylation
Pathways		Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain FOXO-mediated transcription of cell death genes	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway
Drugs			Valproic acid Belinostat Panobinostat
Diseases
GWAS		Adverse response to drug ( 30420678) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Allergic sensitization ( 23817571) Asthma ( 31959851) B cell non-Hodgkin lymphoma ( 23749188) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Blood urea nitrogen levels ( 29403010) Glucose homeostasis traits ( 25524916) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494) PR interval ( 23534349) Pulmonary function (smoking interaction) ( 23284291) Renal function-related traits (BUN) ( 22797727) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Triglyceride levels ( 32203549) Type 2 diabetes ( 25760438)	Abdominal aortic calcification levels ( 31659325) Brain morphology (MOSTest) ( 32665545) Cerebral amyloid angiopathy ( 25188341) Colorectal cancer x fine particulate matter exposure levels interaction ( 33338681) Coronary artery disease ( 32469254 30104761 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or large artery stroke ( 24262325) Cortical surface area (visual PC2) ( 32198502) Cortical volume ( 32963231) Depressive symptom (fatigue) (ordinal trait) ( 31530331) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Fasting blood glucose ( 31217584) Fasting glucose ( 34074324) Height ( 31562340) Iris color (b* coordinate) ( 30895295) Ischemic stroke ( 26708676 29531354) Ischemic stroke (large artery atherosclerosis) ( 26708676 29531354) Large artery stroke ( 28265093 24262325) Large artery stroke (CCS and TOAST classification) ( 32047268) Large artery stroke (CCS or TOAST classification) ( 32047268) Large artery stroke (CCSp classification)j ( 32047268) Large artery stroke (TOAST classification) ( 32047268) Late-onset Alzheimer's disease ( 27770636) Loneliness ( 27629369) Male-pattern baldness ( 22693459 27182965 28196072) Mean corpuscular hemoglobin concentration ( 32888494) Metabolite levels ( 31628463) Moderate-to-late spontaneous preterm birth ( 31194736) Monobrow ( 27182965) Moyamoya disease ( 29273593) Myocardial infarction ( 33532862) Neuritic plaques or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Neuritic plaques or neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Osteoarthritis (hip) ( 30374069) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Peripheral artery disease ( 26488411 31285632) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Pulse pressure ( 26390057 27841878 29403010 28739976 30487518) Reading disability ( 32108986) Reasoning ( 29907492) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Resting-state electroencephalogram vigilance ( 29703947) Retinopathy in non-diabetics ( 23393555) Stroke ( 22306652 26089329 29531354) Stroke (ischemic) ( 23041239) Subcortical volume (MOSTest) ( 32665545) Systemic juvenile idiopathic arthritis ( 27927641) Systolic blood pressure ( 27841878 30487518) Type 2 diabetes (age of onset) ( 28060188) Ulcerative colitis ( 20848476) Zinc levels ( 26025379)
Interacting Genes		90 interacting genes: ANKRD53 ARHGEF9 ARRDC3 ATP23 BCL11A BCL6B BCOR BLZF1 C4orf45 C7orf31 C9orf24 CABP4 CDK19 CDK8 CFAP161 CFAP97D1 CHD3 CNOT2 CRBN CREBBP CTNNB1 CUTC DVL2 DVL3 ENO1 EP300 FBXO11 GATA1 GLRX3 GOLGA2 HDAC1 HDAC4 HDAC5 HDAC7 HDAC9 IHO1 IRF4 JUN JUNB JUND KIFC3 KLHL12 KLHL20 KRTAP13-1 KRTAP13-2 KRTAP19-1 LIMS3 LIMS4 MAPK1 MDFI MED17 MED6 MTA3 MTUS2 NCOR1 NCOR2 PBX4 PELI1 PFDN5 PIN1 PML POF1B PPARD PPTC7 PRKD3 PSMB4 RAF1 REL RUNX1T1 SIAH1 SIN3A SP1 SPI1 SSX2IP TEKT4 TFIP11 TLE5 TP53 TP53BP1 TRAF1 TRAF2 TRIB3 TWIST1 WDR83 WNK4 ZBTB16 ZBTB17 ZBTB7A ZBTB7B ZNHIT1	29 interacting genes: ANKRA2 BCL6 CBX5 CTBP1 ESR1 ETV6 H3C15 H4-16 HDAC1 HDAC3 HDAC4 JUN MAML1 MAPK10 MAPK8 MAPK9 MEF2A MEF2C NCOR1 PKD1 SIN3A SIN3B SUMO1 SUMO2 SYK TRIM29 USF1 YWHAZ ZBTB16
Entrez ID		604	9734
HPRD ID		00180	05944
Ensembl ID		ENSG00000113916	ENSG00000048052
Uniprot IDs		B5B0A5 P41182	B7Z3P7 Q9UKV0
PDB IDs		1R28 1R29 1R2B 2EN2 2EOS 2LCE 2YRM 3BIM 3E4U 3LBZ 4CP3 4U2M 5H7G 5H7H 5MW2 5MW6 5MWD 5N1X 5N1Z 5N20 5N21 5X4M 5X4N 5X4O 5X4P 5X4Q 5X9O 5X9P 6C3L 6C3N 6CQ1 6EW6 6EW7 6EW8 6TOF 6TOG 6TOH 6TOI 6TOJ 6TOK 6TOL 6TOM 6TON 6TOO 6XMX 6XWF 6XXS 6XYX 6XZZ 6Y17 6ZBU
Enriched GO Terms of Interacting Partners?
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