HDAC9 and MAPK9

Number of citations of the paper that reports this interaction (PubMedID 16611996)
44

Data Source:
BioGRID (affinity chromatography technology, pull down)

		HDAC9	MAPK9
Description		histone deacetylase 9	mitogen-activated protein kinase 9
Image		No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Histone Methyltransferase Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Transcription Corepressor Activity Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Activity (H4-K16 Specific) Histone Deacetylase Binding Metal Ion Binding DNA-binding Transcription Factor Binding	Protein Serine/threonine Kinase Activity JUN Kinase Activity MAP Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cytokine Production Response To Amphetamine Inflammatory Response Heart Development Histone Deacetylation Neuron Differentiation B Cell Differentiation Cellular Response To Insulin Stimulus Peptidyl-lysine Deacetylation B Cell Activation Cholesterol Homeostasis Negative Regulation Of Transcription, DNA-templated Regulation Of Skeletal Muscle Fiber Development Negative Regulation Of Lipoprotein Lipase Activity Regulation Of Striated Muscle Cell Differentiation Histone H3 Deacetylation Histone H4 Deacetylation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Histone H4-K16 Deacetylation	Protein Phosphorylation JNK Cascade Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Peptidyl-serine Phosphorylation Positive Regulation Of Protein Ubiquitination Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Regulation Of DNA-binding Transcription Factor Activity Protein Localization To Tricellular Tight Junction Cellular Response To Cadmium Ion Positive Regulation Of Podosome Assembly Cellular Senescence Positive Regulation Of Transcription Factor Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway	Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors
Drugs		Valproic acid Belinostat Panobinostat	Minocycline N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide Fostamatinib Halicin
Diseases
GWAS		Abdominal aortic calcification levels ( 31659325) Brain morphology (MOSTest) ( 32665545) Cerebral amyloid angiopathy ( 25188341) Colorectal cancer x fine particulate matter exposure levels interaction ( 33338681) Coronary artery disease ( 32469254 30104761 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or large artery stroke ( 24262325) Cortical surface area (visual PC2) ( 32198502) Cortical volume ( 32963231) Depressive symptom (fatigue) (ordinal trait) ( 31530331) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Fasting blood glucose ( 31217584) Fasting glucose ( 34074324) Height ( 31562340) Iris color (b* coordinate) ( 30895295) Ischemic stroke ( 26708676 29531354) Ischemic stroke (large artery atherosclerosis) ( 26708676 29531354) Large artery stroke ( 28265093 24262325) Large artery stroke (CCS and TOAST classification) ( 32047268) Large artery stroke (CCS or TOAST classification) ( 32047268) Large artery stroke (CCSp classification)j ( 32047268) Large artery stroke (TOAST classification) ( 32047268) Late-onset Alzheimer's disease ( 27770636) Loneliness ( 27629369) Male-pattern baldness ( 22693459 27182965 28196072) Mean corpuscular hemoglobin concentration ( 32888494) Metabolite levels ( 31628463) Moderate-to-late spontaneous preterm birth ( 31194736) Monobrow ( 27182965) Moyamoya disease ( 29273593) Myocardial infarction ( 33532862) Neuritic plaques or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Neuritic plaques or neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Osteoarthritis (hip) ( 30374069) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Peripheral artery disease ( 26488411 31285632) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Pulse pressure ( 26390057 27841878 29403010 28739976 30487518) Reading disability ( 32108986) Reasoning ( 29907492) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Resting-state electroencephalogram vigilance ( 29703947) Retinopathy in non-diabetics ( 23393555) Stroke ( 22306652 26089329 29531354) Stroke (ischemic) ( 23041239) Subcortical volume (MOSTest) ( 32665545) Systemic juvenile idiopathic arthritis ( 27927641) Systolic blood pressure ( 27841878 30487518) Type 2 diabetes (age of onset) ( 28060188) Ulcerative colitis ( 20848476) Zinc levels ( 26025379)	Blood protein levels ( 30072576)
Interacting Genes		29 interacting genes: ANKRA2 BCL6 CBX5 CTBP1 ESR1 ETV6 H3C15 H4-16 HDAC1 HDAC3 HDAC4 JUN MAML1 MAPK10 MAPK8 MAPK9 MEF2A MEF2C NCOR1 PKD1 SIN3A SIN3B SUMO1 SUMO2 SYK TRIM29 USF1 YWHAZ ZBTB16	113 interacting genes: ACP5 AKT1 ARRB1 ARRB2 ATF2 ATF7 BCL2L1 BCL2L11 BNIP5 C1orf105 C1orf94 CASP3 CBLL2 CCDC33 CDC16 CDC25B CDC25C CEP126 CEP44 CLU CTBP1 CTNNB1 CYHR1 DCX DTX3 DUSP10 DUSP16 DUSP19 DUSP4 EEF2K EFHC2 EGFR ELK1 ELK3 ENKD1 FBXO7 GFAP GOLGA6A GRB2 GSC2 H3-3A HDAC9 HSF1 IHO1 IRS1 ITGB3BP JDP2 JUN JUNB JUND KLHL8 KPNA3 L3MBTL3 LHX3 LMAN2 LNX1 LNX2 LZTS1 MACF1 MAP2K4 MAP2K7 MAP3K1 MAP3K10 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAPK5 MAPKBP1 MAPT MCRS1 MED12L MEOX1 MLIP NCF1 NCSTN NFATC3 NFATC4 NHSL2 PAX5 PBX4 PICK1 POU6F2 PPARG PRKD1 PSEN1 RASL10B RB1 RPS6KB1 RSPO4 SAXO1 SDCBP SF3B4 SH3BP5 SHMT1 SLIT3 SMAD2 SMAD3 SMCO3 SSU72 TCP10L TEX11 TOB1 TP53 TRAF2 TUSC2 WDR62 XPNPEP1 XPO7 ZBTB25 ZC2HC1C ZNF138 ZNF559 ZNHIT1
Entrez ID		9734	5601
HPRD ID		05944	04206
Ensembl ID		ENSG00000048052	ENSG00000050748
Uniprot IDs		B7Z3P7 Q9UKV0	D7R525 D7R526 P45984
PDB IDs			3E7O 3NPC 7CML
Enriched GO Terms of Interacting Partners?
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