HDAC9 and HDAC3

Number of citations of the paper that reports this interaction (PubMedID 11466315)
74

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		HDAC9	HDAC3
Description		histone deacetylase 9	histone deacetylase 3
Image		No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Histone Methyltransferase Complex	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Transcription Repressor Complex Mitotic Spindle
	Molecular Function	Transcription Corepressor Activity Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Activity (H4-K16 Specific) Histone Deacetylase Binding Metal Ion Binding DNA-binding Transcription Factor Binding	Transcription Corepressor Binding Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Enzyme Binding Cyclin Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding NF-kappaB Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cytokine Production Response To Amphetamine Inflammatory Response Heart Development Histone Deacetylation Neuron Differentiation B Cell Differentiation Cellular Response To Insulin Stimulus Peptidyl-lysine Deacetylation B Cell Activation Cholesterol Homeostasis Negative Regulation Of Transcription, DNA-templated Regulation Of Skeletal Muscle Fiber Development Negative Regulation Of Lipoprotein Lipase Activity Regulation Of Striated Muscle Cell Differentiation Histone H3 Deacetylation Histone H4 Deacetylation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Histone H4-K16 Deacetylation	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Phosphorylation Chromatin Organization Protein Deacetylation Negative Regulation Of Myotube Differentiation Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Positive Regulation Of TOR Signaling Circadian Regulation Of Gene Expression Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Spindle Assembly Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Fluid Shear Stress Positive Regulation Of Cold-induced Thermogenesis
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway	NR1D1 (REV-ERBA) represses gene expression p75NTR negatively regulates cell cycle via SC1 PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Association of TriC/CCT with target proteins during biosynthesis Regulation of lipid metabolism by PPARalpha Circadian Clock Circadian Clock Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX2 regulates osteoblast differentiation Regulation of PTEN gene transcription Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events STAT3 nuclear events downstream of ALK signaling Cytoprotection by HMOX1 Heme signaling Heme signaling
Drugs		Valproic acid Belinostat Panobinostat	Vorinostat Belinostat Pracinostat Panobinostat Mocetinostat
Diseases
GWAS		Abdominal aortic calcification levels ( 31659325) Brain morphology (MOSTest) ( 32665545) Cerebral amyloid angiopathy ( 25188341) Colorectal cancer x fine particulate matter exposure levels interaction ( 33338681) Coronary artery disease ( 32469254 30104761 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or large artery stroke ( 24262325) Cortical surface area (visual PC2) ( 32198502) Cortical volume ( 32963231) Depressive symptom (fatigue) (ordinal trait) ( 31530331) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Fasting blood glucose ( 31217584) Fasting glucose ( 34074324) Height ( 31562340) Iris color (b* coordinate) ( 30895295) Ischemic stroke ( 26708676 29531354) Ischemic stroke (large artery atherosclerosis) ( 26708676 29531354) Large artery stroke ( 28265093 24262325) Large artery stroke (CCS and TOAST classification) ( 32047268) Large artery stroke (CCS or TOAST classification) ( 32047268) Large artery stroke (CCSp classification)j ( 32047268) Large artery stroke (TOAST classification) ( 32047268) Late-onset Alzheimer's disease ( 27770636) Loneliness ( 27629369) Male-pattern baldness ( 22693459 27182965 28196072) Mean corpuscular hemoglobin concentration ( 32888494) Metabolite levels ( 31628463) Moderate-to-late spontaneous preterm birth ( 31194736) Monobrow ( 27182965) Moyamoya disease ( 29273593) Myocardial infarction ( 33532862) Neuritic plaques or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Neuritic plaques or neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Osteoarthritis (hip) ( 30374069) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Peripheral artery disease ( 26488411 31285632) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Pulse pressure ( 26390057 27841878 29403010 28739976 30487518) Reading disability ( 32108986) Reasoning ( 29907492) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Resting-state electroencephalogram vigilance ( 29703947) Retinopathy in non-diabetics ( 23393555) Stroke ( 22306652 26089329 29531354) Stroke (ischemic) ( 23041239) Subcortical volume (MOSTest) ( 32665545) Systemic juvenile idiopathic arthritis ( 27927641) Systolic blood pressure ( 27841878 30487518) Type 2 diabetes (age of onset) ( 28060188) Ulcerative colitis ( 20848476) Zinc levels ( 26025379)	Refractive error ( 32231278)
Interacting Genes		29 interacting genes: ANKRA2 BCL6 CBX5 CTBP1 ESR1 ETV6 H3C15 H4-16 HDAC1 HDAC3 HDAC4 JUN MAML1 MAPK10 MAPK8 MAPK9 MEF2A MEF2C NCOR1 PKD1 SIN3A SIN3B SUMO1 SUMO2 SYK TRIM29 USF1 YWHAZ ZBTB16	102 interacting genes: ANKRD11 ANKRD12 AR ARID4A ATF3 BCL3 BCOR BRINP1 BRIP1 BRMS1 CBFA2T3 CCN5 CCND1 CCT5 CEBPD CORO2A CREB3 CREBBP CSNK2A1 CTBP1 DAXX DHX30 EED ELL EP300 ESR1 EWSR1 GATA1 GATA2 GATA3 GCM1 GPS2 GTF2I GTF2IRD1 H2AC1 H2BC1 H3C1 H4C1 HDAC1 HDAC10 HDAC4 HDAC5 HDAC7 HDAC9 HIF1A HIF1AN HNF4A HR HSPA4 HSPA8 IL16 JUN KLF6 LCOR MAPK11 MAPK14 MBD1 NACC1 NCOR1 NCOR2 NFKBIA NR0B2 NR2C1 NR2E3 NRIP1 PARP1 PHB2 PIAS2 PML PPARD PPARG PPP4C PPP4R1 PRKDC RARA RB1 RBBP4 RELA RUNX1T1 RUNX2 RXRA SMYD1 SRC SRY STAT3 SUV39H1 SYK TAB2 TBL1X TBL1XR1 THAP11 THAP7 THRA THRB TMPO TNFRSF14 TP53 TXNIP VHL XPO1 YY1 ZBTB16
Entrez ID		9734	8841
HPRD ID		05944	08950
Ensembl ID		ENSG00000048052	ENSG00000171720
Uniprot IDs		B7Z3P7 Q9UKV0	O15379
PDB IDs			4A69
Enriched GO Terms of Interacting Partners?
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