RGL1 and RIT1

Number of citations of the paper that reports this interaction (PubMedID 10545207)
27

Data Source:
HPRD (in vitro)

		RGL1	RIT1
Description		ral guanine nucleotide dissociation stimulator like 1	Ras like without CAAX 1
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol	Plasma Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	GTPase Activity G Protein Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding
	Biological Process	Small GTPase Mediated Signal Transduction Regulation Of Catalytic Activity	Signal Transduction Ras Protein Signal Transduction
Pathways		PPARA activates gene expression RAF/MAP kinase cascade	Signalling to p38 via RIT and RIN
Drugs
Diseases
GWAS		Antipsychotic drug-induced QTc interval change in schizophrenia ( 29064910) Aspartate aminotransferase levels ( 33547301 29403010 33339817) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hip circumference adjusted for BMI ( 34021172) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Immature fraction of reticulocytes ( 32888494) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Response to antidepressants ( 20360315) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Retinal detachment or retinal break ( 31816047)	Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908 23128233) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		5 interacting genes: APP HRAS RAP2A RIT1 RIT2	17 interacting genes: AFDN AP2A1 CUL3 IFRD1 KLHL12 LRIF1 LRRK2 LZTR1 PTN RALGDS RGL1 RGL3 RLF SMAD2 SMAD3 SMURF1 SRPK2
Entrez ID		23179	6016
HPRD ID		12032	10195
Ensembl ID		ENSG00000143344	ENSG00000143622
Uniprot IDs		B7Z2W5 B7Z915 B7ZB61 Q9NZL6	Q92963
PDB IDs			4KLZ
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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