RFX5 and CIITA

Number of citations of the paper that reports this interaction (PubMedID 9177217)
40

Data Source:
HPRD (in vitro)

		RFX5	CIITA
Description		regulatory factor X5	class II major histocompatibility complex transactivator
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin RNA Polymerase II Transcription Regulator Complex	Nucleoplasm Cytosol PML Body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding DNA Binding Transcription Coactivator Activity Protein Binding ATP Binding GTP Binding Protein C-terminus Binding Acyltransferase Activity Protein-containing Complex Binding Protein Serine Kinase Activity DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Inflammatory Response Immune Response Negative Regulation Of Collagen Biosynthetic Process Response To Interferon-gamma Positive Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Viral Entry Into Host Cell Response To Antibiotic
Pathways			Interferon gamma signaling
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Alopecia areata ( 25608926) Asthma ( 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Celiac disease ( 22057235 20190752) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Nasopharyngeal carcinoma ( 27436580) Systemic lupus erythematosus ( 27399966 26502338) Ulcerative colitis ( 20228799)
Interacting Genes		7 interacting genes: APP CIITA HDAC2 MUC1 RFXANK RFXAP TUBD1	17 interacting genes: CDK1 GSK3B GTF2B HDAC1 HDAC4 HDAC5 KAT2B NCOA1 NFYB PRKACA RFX5 RFXANK SMARCA4 TAF6 TAF9 XPO1 ZXDC
Entrez ID		5993	4261
HPRD ID		03517	02475
Ensembl ID		ENSG00000143390	ENSG00000179583
Uniprot IDs		P48382	A0A087X2I7 A0A0B4J1S1 P33076 Q66X48
PDB IDs		2KW3 3V30
Enriched GO Terms of Interacting Partners?
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