CIITA and RFX5

Number of citations of the paper that reports this interaction (PubMedID 9177217)
40

Data Source:
HPRD (in vitro)

		CIITA	RFX5
Description		class II major histocompatibility complex transactivator	regulatory factor X5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol PML Body	Chromatin RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Transcription Coactivator Activity Protein Binding ATP Binding GTP Binding Protein C-terminus Binding Acyltransferase Activity Protein-containing Complex Binding Protein Serine Kinase Activity DNA-binding Transcription Factor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Inflammatory Response Immune Response Negative Regulation Of Collagen Biosynthetic Process Response To Interferon-gamma Positive Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Viral Entry Into Host Cell Response To Antibiotic	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Interferon gamma signaling
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Asthma ( 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Celiac disease ( 22057235 20190752) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Nasopharyngeal carcinoma ( 27436580) Systemic lupus erythematosus ( 27399966 26502338) Ulcerative colitis ( 20228799)	Body mass index ( 26426971)
Interacting Genes		17 interacting genes: CDK1 GSK3B GTF2B HDAC1 HDAC4 HDAC5 KAT2B NCOA1 NFYB PRKACA RFX5 RFXANK SMARCA4 TAF6 TAF9 XPO1 ZXDC	7 interacting genes: APP CIITA HDAC2 MUC1 RFXANK RFXAP TUBD1
Entrez ID		4261	5993
HPRD ID		02475	03517
Ensembl ID		ENSG00000179583	ENSG00000143390
Uniprot IDs		A0A087X2I7 A0A0B4J1S1 P33076 Q66X48	P48382
PDB IDs			2KW3 3V30
Enriched GO Terms of Interacting Partners?
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