CIITA and NFYB

Number of citations of the paper that reports this interaction (PubMedID 11003667)
30

Data Source:
HPRD (in vivo)

		CIITA	NFYB
Description		class II major histocompatibility complex transactivator	nuclear transcription factor Y subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol PML Body	Chromatin Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Transcription Coactivator Activity Protein Binding ATP Binding GTP Binding Protein C-terminus Binding Acyltransferase Activity Protein-containing Complex Binding Protein Serine Kinase Activity DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein-containing Complex Binding Protein Heterodimerization Activity DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Inflammatory Response Immune Response Negative Regulation Of Collagen Biosynthetic Process Response To Interferon-gamma Positive Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Viral Entry Into Host Cell Response To Antibiotic	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Leukemia Inhibitory Factor
Pathways		Interferon gamma signaling	PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Asthma ( 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Celiac disease ( 22057235 20190752) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Nasopharyngeal carcinoma ( 27436580) Systemic lupus erythematosus ( 27399966 26502338) Ulcerative colitis ( 20228799)	Toenail selenium levels ( 25343990)
Interacting Genes		17 interacting genes: CDK1 GSK3B GTF2B HDAC1 HDAC4 HDAC5 KAT2B NCOA1 NFYB PRKACA RFX5 RFXANK SMARCA4 TAF6 TAF9 XPO1 ZXDC	27 interacting genes: AGTRAP C1QBP CEBPZ CIITA CNTN2 DRAP1 DUSP6 ELF1 EP300 GRB2 MAOB MEOX2 MYC NFYA NFYC POLE4 POU3F2 SMYD3 SP1 TAF11 TAF12 TAF6 TBP TP53 TP73 YBX1 YBX3
Entrez ID		4261	4801
HPRD ID		02475	01794
Ensembl ID		ENSG00000179583	ENSG00000120837
Uniprot IDs		A0A087X2I7 A0A0B4J1S1 P33076 Q66X48	A0A024RBG7 F8VSL3 P25208
PDB IDs			1N1J 4AWL 4CSR 6QMP 6QMQ 6QMS
Enriched GO Terms of Interacting Partners?
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