RAP2A and MAP4K4

Number of citations of the paper that reports this interaction (PubMedID 14966141)
45

Data Source:
HPRD (two hybrid)

		RAP2A	MAP4K4
Description		RAP2A, member of RAS oncogene family	mitogen-activated protein kinase kinase kinase kinase 4
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Midbody Recycling Endosome Recycling Endosome Membrane	Cytoplasm Focal Adhesion
	Molecular Function	Magnesium Ion Binding GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding	Creatine Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Microvillus Assembly Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Cellular Protein Localization Establishment Of Protein Localization Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Cellular Response To Xenobiotic Stimulus Protein Localization To Plasma Membrane	MAPK Cascade Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Microvillus Assembly Positive Regulation Of Cell Migration Positive Regulation Of ARF Protein Signal Transduction Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Regulation Of JNK Cascade Neuron Projection Morphogenesis Positive Regulation Of Keratinocyte Migration Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Neuron Projection Regeneration Positive Regulation Of Focal Adhesion Disassembly
Pathways			Oxidative Stress Induced Senescence
Drugs		Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate	Fostamatinib
Diseases
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Peripheral artery disease ( 26488411)	Alzheimer's disease ( 30636644) Asthma ( 31619474) Asthma (time to onset) ( 27130862) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) White blood cell count ( 32888494)
Interacting Genes		34 interacting genes: ACVR1 AFDN ARHGAP29 BMPR1B CDK4 EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D IRS2 MAP4K4 NEDD4 PLG RAF1 RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGL1 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK	18 interacting genes: BRCA1 CASP8 DOK1 GBP3 H2BC21 ITGB1 KIF26B KIF5A MAP3K7 NCK1 NME7 PPP1CA PPP1CC PRKCE RAP2A RASA1 SLC9A1 TBPL2
Entrez ID		5911	9448
HPRD ID		01547	05235
Ensembl ID		ENSG00000125249	ENSG00000071054
Uniprot IDs		P10114	B7Z3V5 O95819 V9HWH3
PDB IDs		1KAO 2RAP 3RAP	4OBO 4OBP 4OBQ 4RVT 4U3Y 4U3Z 4U40 4U41 4U42 4U43 4U44 4U45 4ZK5 4ZP5 5DI1 5J95 5W5Q
Enriched GO Terms of Interacting Partners?
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