RAP2A and RAPGEF6

Number of citations of the paper that reports this interaction (PubMedID 11524421)
21

Data Source:
HPRD (in vitro, in vivo)

		RAP2A	RAPGEF6
Description		RAP2A, member of RAS oncogene family	Rap guanine nucleotide exchange factor 6
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Midbody Recycling Endosome Recycling Endosome Membrane	Centrosome Cytosol Plasma Membrane Apical Plasma Membrane Endocytic Vesicle
	Molecular Function	Magnesium Ion Binding GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP-dependent Protein Binding Small GTPase Binding Phosphatidic Acid Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Microvillus Assembly Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Cellular Protein Localization Establishment Of Protein Localization Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Cellular Response To Xenobiotic Stimulus Protein Localization To Plasma Membrane	Ras Protein Signal Transduction Microvillus Assembly Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier
Pathways
Drugs		Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Peripheral artery disease ( 26488411)	Alzheimer's disease in APOE e4- carriers ( 25778476) Asthma ( 32296059) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diisocyanate-induced asthma ( 25918132) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Perceived unattractiveness to mosquitoes ( 28199695) Subcortical volume (MOSTest) ( 32665545) Subjective well-being ( 27089181) Ulcerative colitis ( 28067908)
Interacting Genes		34 interacting genes: ACVR1 AFDN ARHGAP29 BMPR1B CDK4 EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D IRS2 MAP4K4 NEDD4 PLG RAF1 RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGL1 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK	9 interacting genes: ABCA1 JADE2 LINC00839 MRAS NEDD4 PTPN13 RAP1A RAP2A YWHAG
Entrez ID		5911	51735
HPRD ID		01547	11483
Ensembl ID		ENSG00000125249	ENSG00000158987
Uniprot IDs		P10114	B2RTU6 Q8TEU7
PDB IDs		1KAO 2RAP 3RAP	2D93 3LNY
Enriched GO Terms of Interacting Partners?
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