RAP2A and RASIP1

Number of citations of the paper that reports this interaction (PubMedID 15031288)
33

Data Source:
HPRD (two hybrid)

		RAP2A	RASIP1
Description		RAP2A, member of RAS oncogene family	Ras interacting protein 1
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Midbody Recycling Endosome Recycling Endosome Membrane	Golgi Stack Cell-cell Junction Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Magnesium Ion Binding GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding	Protein Binding Protein Homodimerization Activity GTPase Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Microvillus Assembly Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Cellular Protein Localization Establishment Of Protein Localization Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Cellular Response To Xenobiotic Stimulus Protein Localization To Plasma Membrane	Angiogenesis Vasculogenesis Signal Transduction Negative Regulation Of Autophagy Positive Regulation Of Integrin Activation Negative Regulation Of Rho Protein Signal Transduction Regulation Of GTPase Activity Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Membrane Permeability Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity
Pathways
Drugs		Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Peripheral artery disease ( 26488411)	Alcohol consumption ( 31358974) Alcohol use disorder (total score) ( 30336701) Apolipoprotein A1 levels ( 33730874) Aspartate aminotransferase levels ( 33547301) Bipolar disorder ( 21926972) Blood protein levels in cardiovascular risk ( 28369058) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cooked vegetable consumption ( 32066663) Crohn's disease ( 28067908 21102463) Dietary macronutrient intake ( 23372041) Estimated glomerular filtration rate ( 31015462) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean platelet volume ( 32888494 27863252) Meat-related diet ( 32066663) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Platelet count ( 32888494) Pork consumption ( 32066663) Processed meat consumption ( 32066663) Retinal vascular caliber ( 21060863) Urinary albumin-to-creatinine ratio ( 31511532) Vitamin B levels in ischemic stroke ( 25147783) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		34 interacting genes: ACVR1 AFDN ARHGAP29 BMPR1B CDK4 EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D IRS2 MAP4K4 NEDD4 PLG RAF1 RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGL1 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK	8 interacting genes: ARFGAP1 HRAS LDB2 MRAS RAP1A RAP2A RRAS RRAS2
Entrez ID		5911	54922
HPRD ID		01547	15214
Ensembl ID		ENSG00000125249	ENSG00000105538
Uniprot IDs		P10114	Q5U651 Q7L251 Q8IUR2
PDB IDs		1KAO 2RAP 3RAP	5KHO 5KHQ
Enriched GO Terms of Interacting Partners?
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