RAB5A and OCRL

Number of citations of the paper that reports this interaction (PubMedID 16902405)
73

Data Source:
BioGRID (proximity labelling technology)
HPRD (in vitro, two hybrid, in vivo)

		RAB5A	OCRL
Description		RAB5A, member RAS oncogene family	OCRL inositol polyphosphate-5-phosphatase
Image
GO Annotations	Cellular Component	Ruffle Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Endomembrane System Actin Cytoskeleton Endocytic Vesicle Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Early Endosome Membrane Early Phagosome Somatodendritic Compartment Melanosome Neuronal Cell Body Terminal Bouton Intracellular Membrane-bounded Organelle Axon Terminus Membrane Raft Phagocytic Vesicle Extracellular Exosome Cytoplasmic Side Of Early Endosome Membrane Postsynaptic Early Endosome Anchored Component Of Synaptic Vesicle Membrane	Photoreceptor Outer Segment Nucleus Cytoplasm Lysosome Early Endosome Golgi Stack Golgi-associated Vesicle Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin-coated Vesicle Phagocytic Vesicle Membrane Early Endosome Membrane
	Molecular Function	GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity GTPase Activator Activity Protein Binding Small GTPase Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity Inositol Phosphate Phosphatase Activity
	Biological Process	Intracellular Protein Transport Endocytosis Phagocytosis Regulation Of Endocytosis Synaptic Vesicle Recycling Viral RNA Genome Replication Early Endosome To Late Endosome Transport Positive Regulation Of Exocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Endosome Size Regulation Of Filopodium Assembly Amyloid-beta Clearance By Transcytosis Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis Regulation Of Autophagosome Assembly	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Phosphatidylinositol-3-phosphate Biosynthetic Process Regulation Of GTPase Activity Inositol Phosphate Metabolic Process Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Cilium Assembly Membrane Organization
Pathways		Synthesis of PIPs at the plasma membrane TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Factors involved in megakaryocyte development and platelet production	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis RHOJ GTPase cycle RAC3 GTPase cycle
Drugs		L-methionine (S)-S-oxide Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295)
Interacting Genes		35 interacting genes: AGTR1 ALS2CL ANKFY1 APPL1 APPL2 CHML EEA1 GDI2 GRIK4 HTATIP2 ITSN1 NME2 OCRL RAB37 RABAC1 RABEP1 RABEP2 RABGGTB RASA1 RBSN RIN1 RIN2 RIN3 RIT2 RUFY1 SDCBP SGSM3 STX4 TBC1D15 TBC1D17 TBC1D3C TBC1D3F TRIM14 TSC2 USP6NL	15 interacting genes: CDC42 CLTC GOLGA5 GRB2 LHX3 PHETA1 PHETA2 RAB14 RAB1A RAB31 RAB5A RAB6A RAB8A RAC1 TYMS
Entrez ID		5868	4952
HPRD ID		01542	02395
Ensembl ID		ENSG00000144566	ENSG00000122126
Uniprot IDs		A0A024R2K1 P20339	A0A2X0TVZ9 Q01968 Q504W7
PDB IDs		1N6H 1N6I 1N6K 1N6L 1N6N 1N6O 1N6P 1N6R 1R2Q 1TU3 1TU4 3MJH 4Q9U 7BL1	2KIE 2QV2 3QBT 3QIS 4CMN
Enriched GO Terms of Interacting Partners?
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