RAB5A and CHML

Number of citations of the paper that reports this interaction (PubMedID 8294464)
51

Data Source:
HPRD (in vitro)

		RAB5A	CHML
Description		RAB5A, member RAS oncogene family	CHM like Rab escort protein
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Endomembrane System Actin Cytoskeleton Endocytic Vesicle Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Early Endosome Membrane Early Phagosome Somatodendritic Compartment Melanosome Neuronal Cell Body Terminal Bouton Intracellular Membrane-bounded Organelle Axon Terminus Membrane Raft Phagocytic Vesicle Extracellular Exosome Cytoplasmic Side Of Early Endosome Membrane Postsynaptic Early Endosome Anchored Component Of Synaptic Vesicle Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Rab-protein Geranylgeranyltransferase Complex
	Molecular Function	GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding	GDP-dissociation Inhibitor Activity GTPase Activator Activity Small GTPase Binding
	Biological Process	Intracellular Protein Transport Endocytosis Phagocytosis Regulation Of Endocytosis Synaptic Vesicle Recycling Viral RNA Genome Replication Early Endosome To Late Endosome Transport Positive Regulation Of Exocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Endosome Size Regulation Of Filopodium Assembly Amyloid-beta Clearance By Transcytosis Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis Regulation Of Autophagosome Assembly	Intracellular Protein Transport Small GTPase Mediated Signal Transduction Vesicle-mediated Transport Protein Geranylgeranylation Regulation Of Catalytic Activity
Pathways		Synthesis of PIPs at the plasma membrane TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Factors involved in megakaryocyte development and platelet production	RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs		L-methionine (S)-S-oxide Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295)	Daytime sleep phenotypes ( 27126917)
Interacting Genes		35 interacting genes: AGTR1 ALS2CL ANKFY1 APPL1 APPL2 CHML EEA1 GDI2 GRIK4 HTATIP2 ITSN1 NME2 OCRL RAB37 RABAC1 RABEP1 RABEP2 RABGGTB RASA1 RBSN RIN1 RIN2 RIN3 RIT2 RUFY1 SDCBP SGSM3 STX4 TBC1D15 TBC1D17 TBC1D3C TBC1D3F TRIM14 TSC2 USP6NL	6 interacting genes: RAB1A RAB3A RAB5A RAB6A RABGGTB SERPINC1
Entrez ID		5868	1122
HPRD ID		01542	00341
Ensembl ID		ENSG00000144566	ENSG00000203668
Uniprot IDs		A0A024R2K1 P20339	P26374
PDB IDs		1N6H 1N6I 1N6K 1N6L 1N6N 1N6O 1N6P 1N6R 1R2Q 1TU3 1TU4 3MJH 4Q9U 7BL1
Enriched GO Terms of Interacting Partners?
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