OCRL and RAB31

Number of citations of the paper that reports this interaction (PubMedID 19795375)
14

Data Source:
BioGRID (pull down)

		OCRL	RAB31
Description		OCRL inositol polyphosphate-5-phosphatase	RAB31, member RAS oncogene family
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Nucleus Cytoplasm Lysosome Early Endosome Golgi Stack Golgi-associated Vesicle Trans-Golgi Network Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin-coated Vesicle Phagocytic Vesicle Membrane Early Endosome Membrane	Phagocytic Cup Early Endosome Cytosol Plasma Membrane Endomembrane System Secretory Granule Membrane Early Endosome Membrane Trans-Golgi Network Membrane Early Phagosome Membrane Phagocytic Vesicle
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity GTPase Activator Activity Protein Binding Small GTPase Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity Inositol Phosphate Phosphatase Activity	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Phosphatidylinositol-3-phosphate Biosynthetic Process Regulation Of GTPase Activity Inositol Phosphate Metabolic Process Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Cilium Assembly Membrane Organization	Intracellular Protein Transport Receptor Internalization Cellular Response To Insulin Stimulus Golgi To Plasma Membrane Protein Transport Regulated Exocytosis Positive Regulation Of Phagocytosis, Engulfment Phagosome Maturation
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis RHOJ GTPase cycle RAC3 GTPase cycle	Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS			Age at first sexual intercourse ( 27089180) Basophil count ( 32888494) Blood pressure (age interaction) ( 24954895) Bone fracture in osteoporosis ( 28580392) Dupuytren's disease ( 28886342) Lung adenocarcinoma ( 28604730)
Interacting Genes		15 interacting genes: CDC42 CLTC GOLGA5 GRB2 LHX3 PHETA1 PHETA2 RAB14 RAB1A RAB31 RAB5A RAB6A RAB8A RAC1 TYMS	7 interacting genes: ALS2CL EEA1 EGFR IRAK1 MAPK6 MPP3 OCRL
Entrez ID		4952	11031
HPRD ID		02395	05751
Ensembl ID		ENSG00000122126	ENSG00000168461
Uniprot IDs		A0A2X0TVZ9 Q01968 Q504W7	Q13636
PDB IDs		2KIE 2QV2 3QBT 3QIS 4CMN	2FG5
Enriched GO Terms of Interacting Partners?
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