RAB4A and ACTB

Number of citations of the paper that reports this interaction (PubMedID 9013719)
1

Data Source:
HPRD (in vitro, in vivo)

		RAB4A	ACTB
Description		RAB4A, member RAS oncogene family	actin beta
Image
GO Annotations	Cellular Component	Endosome Cytosol Plasma Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane Vesicle Insulin-responsive Compartment Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome Postsynaptic Recycling Endosome Anchored Component Of Synaptic Vesicle Membrane	Chromatin Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Adherens Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Axon Cortical Cytoskeleton Vesicle Protein-containing Complex NuA4 Histone Acetyltransferase Complex Cytoplasmic Ribonucleoprotein Granule Apical Junction Complex Calyx Of Held Synapse Extracellular Exosome Tight Junction Blood Microparticle Dense Body Schaffer Collateral - CA1 Synapse Presynapse Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Ribonucleoprotein Complex
	Molecular Function	ATPase Activator Activity GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding Syntaxin Binding Ionotropic Glutamate Receptor Binding ATPase Binding	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Kinesin Binding Protein Kinase Binding Tat Protein Binding Nucleosomal DNA Binding Identical Protein Binding Tau Protein Binding Nitric-oxide Synthase Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton
	Biological Process	Protein Transport Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Regulation Of Catalytic Activity	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Morphogenesis Of A Polarized Epithelium Retina Homeostasis Chromatin Remodeling Establishment Or Maintenance Of Cell Polarity Axonogenesis Substantia Nigra Development Regulation Of Transmembrane Transporter Activity Negative Regulation Of Protein Binding Adherens Junction Assembly Maintenance Of Blood-brain Barrier Apical Protein Localization Synaptic Vesicle Endocytosis Cell Motility Regulation Of Norepinephrine Uptake Positive Regulation Of Norepinephrine Uptake Platelet Aggregation Protein Localization To Adherens Junction Cellular Response To Cytochalasin B Postsynaptic Actin Cytoskeleton Organization Regulation Of Transepithelial Transport Regulation Of Protein Localization To Plasma Membrane
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Synthesis of PIPs at the plasma membrane TBC/RABGAPs RAB geranylgeranylation MET receptor recycling	Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation HATs acetylate histones Prefoldin mediated transfer of substrate to CCT/TriC Folding of actin by CCT/TriC EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions B-WICH complex positively regulates rRNA expression RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation UCH proteinases DNA Damage Recognition in GG-NER Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis RHOF GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production
Drugs			Quercetin Phenethyl Isothiocyanate
Diseases
GWAS		Aging ( 22773346) Leukoderma in response to rhododendrol ( 32558222) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Mercury levels ( 26025379) Response to antidepressants in depression ( 27622933)	Global electrical heterogeneity phenotypes ( 29622589) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Relative hand skill in reading disability ( 24068947) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		33 interacting genes: ACTB APBB3 CD2AP CDK1 CHM DYNC1LI1 DYNLL1 EXOC5 FAM71C GDI2 GRIPAP1 HACE1 IDH3A KCTD7 KIF3B MAPK3 PIN1 PRKCI PTTG1IP RAB11FIP1 RAB7A RABAC1 RABEP1 RABEP2 RABGAP1 RABGEF1 RBSN RUFY1 SOD2 STX4 TP53 VPS52 ZNF830	161 interacting genes: A2M ABLIM1 ABRA ACD ACTC1 ACTG1 AIMP2 ALOX5 ANXA7 AQP2 AR ARPC1B ATF7IP BBS4 BCL2L1 CAP1 CAPZA1 CCN2 CCT2 CCT4 CCT5 CCT8 CDC37 CDK5R2 CDKN1A CDKN2A CFL1 CFL2 CLIC4 CLNS1A CNN2 CORO1A CORO7 COTL1 CPNE1 CPNE2 CPNE4 CREBBP CSNK1A1 CSNK2B DMTN DNASE1 DSTN DUSP19 DYNLL1 EEF1A1 EHHADH EMD EP300 ERG EZR FABP4 FHL3 FLII FXR1 GAPDH GNA12 GSN H2AX HCK HIP1R HMMR HNRNPAB HNRNPD HNRNPU HSD17B4 HSPB2 HTR6 KHDRBS1 LASP1 LGALS13 LINC01554 LINC02582 LMNA LMOD1 LRRK2 LYN MAP1B MAP2 MAPT MRGBP MTNR1A MX1 MYO18B MYO1E MYOC NCALD NCF1 NDEL1 NEBL NOS2 NRAP NSMAF NT5E NTAQ1 OGT P2RX7 PCYT1A PDIA2 PDLIM5 PFDN1 PFDN4 PFN1 PFN2 PHACTR4 PLD1 PLD2 PLG POLR2A POT1 PRKCD PROSER2 PTN PTPRF RAB4A RAC1 RAC2 RALA RCC1 RPL10A S100A11 SAMHD1 SCN10A SHBG SMAD3 SMAD9 SMARCA4 SMN1 SPTAN1 SPTB SPTBN2 SRPK2 SSH1 SSH2 SSH3 STX4 SUMO2 SYNJ2BP TANC1 TCF12 TGM2 TINF2 TK1 TMSB4X TMSB4XP1 TMSB4XP4 TNNI2 TPM1 TPM2 TPM3 TRIM15 TSHR TTR UBE2I UBE3A VHL VSNL1 WASF1 WASF2 WASF3 XPO6
Entrez ID		5867	60
HPRD ID		01541	00032
Ensembl ID		ENSG00000168118	ENSG00000075624
Uniprot IDs		A0A024R3U9 A0A087WYT5 P20338	P60709 Q1KLZ0
PDB IDs		1YU9 1Z0K 2BMD 2BME	3BYH 3D2U 3J82 3LUE 6ANU 6ICT 6ICV 6LTJ 6MBJ 6MBK 6MBL 6NBW 6OX0 6OX1 6OX2 6OX3 6OX4 6OX5 6V62 6V63 6WK1 6WK2 7AS4
Enriched GO Terms of Interacting Partners?
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