ACTB and LRRK2

Number of citations of the paper that reports this interaction (PubMedID 20876399)
55

Data Source:
BioGRID (pull down)

		ACTB	LRRK2
Description		actin beta	leucine rich repeat kinase 2
Image
GO Annotations	Cellular Component	Chromatin Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell-cell Junction Adherens Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Axon Cortical Cytoskeleton Vesicle Protein-containing Complex NuA4 Histone Acetyltransferase Complex Cytoplasmic Ribonucleoprotein Granule Apical Junction Complex Calyx Of Held Synapse Extracellular Exosome Tight Junction Blood Microparticle Dense Body Schaffer Collateral - CA1 Synapse Presynapse Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Ribonucleoprotein Complex	Golgi Membrane Extracellular Space Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Golgi-associated Vesicle Trans-Golgi Network Cytosol Plasma Membrane Microvillus Inclusion Body Axon Dendrite Growth Cone Synaptic Vesicle Membrane Cytoplasmic Vesicle Mitochondrial Membrane Cytoplasmic Side Of Mitochondrial Outer Membrane Dendrite Cytoplasm Neuron Projection Neuronal Cell Body Terminal Bouton Perikaryon Intracellular Membrane-bounded Organelle Amphisome Autolysosome Membrane Raft Extracellular Exosome Endoplasmic Reticulum Exit Site Multivesicular Body, Internal Vesicle Postsynapse Glutamatergic Synapse Caveola Neck Presynaptic Cytosol Ribonucleoprotein Complex Wnt Signalosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Kinesin Binding Protein Kinase Binding Tat Protein Binding Nucleosomal DNA Binding Identical Protein Binding Tau Protein Binding Nitric-oxide Synthase Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton	SNARE Binding Magnesium Ion Binding Actin Binding GTPase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Serine/threonine Phosphatase Activity GTPase Activator Activity Protein Binding ATP Binding GTP Binding Microtubule Binding Tubulin Binding Kinase Activity Syntaxin-1 Binding Signaling Receptor Complex Adaptor Activity Clathrin Binding Small GTPase Binding GTP-dependent Protein Kinase Activity Peroxidase Inhibitor Activity Co-receptor Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein Kinase A Binding Protein Serine Kinase Activity Beta-catenin Destruction Complex Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Morphogenesis Of A Polarized Epithelium Retina Homeostasis Chromatin Remodeling Establishment Or Maintenance Of Cell Polarity Axonogenesis Substantia Nigra Development Regulation Of Transmembrane Transporter Activity Negative Regulation Of Protein Binding Adherens Junction Assembly Maintenance Of Blood-brain Barrier Apical Protein Localization Synaptic Vesicle Endocytosis Cell Motility Regulation Of Norepinephrine Uptake Positive Regulation Of Norepinephrine Uptake Platelet Aggregation Protein Localization To Adherens Junction Cellular Response To Cytochalasin B Postsynaptic Actin Cytoskeleton Organization Regulation Of Transepithelial Transport Regulation Of Protein Localization To Plasma Membrane	MAPK Cascade Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Protein Dephosphorylation Protein Import Into Nucleus Endocytosis Autophagy Response To Oxidative Stress Mitochondrion Organization Endoplasmic Reticulum Organization Golgi Organization Lysosome Organization Signal Transduction JNK Cascade Spermatogenesis Neuromuscular Junction Development Determination Of Adult Lifespan Cellular Response To Starvation Regulation Of Autophagy Positive Regulation Of Autophagy Regulation Of Protein Kinase A Signaling Negative Regulation Of Protein Processing Negative Regulation Of Neuron Projection Development Regulation Of Neuron Maturation Negative Regulation Of Macroautophagy Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Calcium-mediated Signaling Striatum Development Olfactory Bulb Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of GTPase Activity Cellular Response To Oxidative Stress Cellular Protein Localization Intracellular Signal Transduction Regulation Of Kidney Size Exploration Behavior Locomotory Exploration Behavior Regulation Of Lysosomal Lumen PH Regulation Of Locomotion Regulation Of Membrane Potential Positive Regulation Of Programmed Cell Death Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Kinase Activity GTP Metabolic Process Protein Autophosphorylation Intracellular Distribution Of Mitochondria Neuron Projection Morphogenesis Mitochondrion Localization Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Regulation Of Mitochondrial Depolarization Regulation Of Synaptic Transmission, Glutamatergic Canonical Wnt Signaling Pathway Excitatory Postsynaptic Potential Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Canonical Wnt Signaling Pathway Regulation Of Dendritic Spine Morphogenesis Protein Localization To Mitochondrion Protein Localization To Endoplasmic Reticulum Exit Site Neuron Death Cellular Response To Manganese Ion Cellular Response To Organic Cyclic Compound Reactive Oxygen Species Metabolic Process Regulation Of Mitochondrial Fission Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Excitatory Postsynaptic Potential Neuron Projection Arborization Positive Regulation Of Synaptic Vesicle Endocytosis Regulation Of Neuron Death Negative Regulation Of Neuron Death Positive Regulation Of Histone Deacetylase Activity Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Autoubiquitination Regulation Of Neuroblast Proliferation Regulation Of Synaptic Vesicle Transport Negative Regulation Of Late Endosome To Lysosome Transport Negative Regulation Of Autophagosome Assembly Negative Regulation Of Thioredoxin Peroxidase Activity By Peptidyl-threonine Phosphorylation Negative Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Cellular Response To Dopamine Positive Regulation Of Microglial Cell Activation Wnt Signalosome Assembly Regulation Of Retrograde Transport, Endosome To Golgi Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Exocytosis Negative Regulation Of Peroxidase Activity
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation HATs acetylate histones Prefoldin mediated transfer of substrate to CCT/TriC Folding of actin by CCT/TriC EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions B-WICH complex positively regulates rRNA expression RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation UCH proteinases DNA Damage Recognition in GG-NER Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis RHOF GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production	PTK6 promotes HIF1A stabilization
Drugs		Quercetin Phenethyl Isothiocyanate	Fostamatinib
Diseases
GWAS		Global electrical heterogeneity phenotypes ( 29622589) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Relative hand skill in reading disability ( 24068947) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549)	Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 21102463) Daytime sleep phenotypes ( 27126917) Inflammatory bowel disease ( 28067908 23128233) Leprosy ( 25642632) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494) Obesity-related traits ( 23251661) Parkinson's disease ( 21292315 19915576 25064009 31660654 27182965 24842889 28892059 22438815 28011712 21738487) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pediatric autoimmune diseases ( 26301688) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		161 interacting genes: A2M ABLIM1 ABRA ACD ACTC1 ACTG1 AIMP2 ALOX5 ANXA7 AQP2 AR ARPC1B ATF7IP BBS4 BCL2L1 CAP1 CAPZA1 CCN2 CCT2 CCT4 CCT5 CCT8 CDC37 CDK5R2 CDKN1A CDKN2A CFL1 CFL2 CLIC4 CLNS1A CNN2 CORO1A CORO7 COTL1 CPNE1 CPNE2 CPNE4 CREBBP CSNK1A1 CSNK2B DMTN DNASE1 DSTN DUSP19 DYNLL1 EEF1A1 EHHADH EMD EP300 ERG EZR FABP4 FHL3 FLII FXR1 GAPDH GNA12 GSN H2AX HCK HIP1R HMMR HNRNPAB HNRNPD HNRNPU HSD17B4 HSPB2 HTR6 KHDRBS1 LASP1 LGALS13 LINC01554 LINC02582 LMNA LMOD1 LRRK2 LYN MAP1B MAP2 MAPT MRGBP MTNR1A MX1 MYO18B MYO1E MYOC NCALD NCF1 NDEL1 NEBL NOS2 NRAP NSMAF NT5E NTAQ1 OGT P2RX7 PCYT1A PDIA2 PDLIM5 PFDN1 PFDN4 PFN1 PFN2 PHACTR4 PLD1 PLD2 PLG POLR2A POT1 PRKCD PROSER2 PTN PTPRF RAB4A RAC1 RAC2 RALA RCC1 RPL10A S100A11 SAMHD1 SCN10A SHBG SMAD3 SMAD9 SMARCA4 SMN1 SPTAN1 SPTB SPTBN2 SRPK2 SSH1 SSH2 SSH3 STX4 SUMO2 SYNJ2BP TANC1 TCF12 TGM2 TINF2 TK1 TMSB4X TMSB4XP1 TMSB4XP4 TNNI2 TPM1 TPM2 TPM3 TRIM15 TSHR TTR UBE2I UBE3A VHL VSNL1 WASF1 WASF2 WASF3 XPO6	146 interacting genes: ABLIM1 ACTB AFF4 AHCYL1 AHDC1 AKT1 ANKS4B ANO6 APEX2 APP ARFGAP1 ARHGEF7 AURKB BAG1 BAG2 BAG3 C18orf25 C1orf87 CAMK1D CBLB CCDC43 CDC42EP3 CDKL3 CETN3 CHGB CRMP1 CUEDC1 CXCL11 CYREN DBF4B DDIT4 DIDO1 DUX3 DVL1 DVL2 DVL3 DYRK2 E2F4 ECHS1 EIF4EBP1 ENKUR ESRRG FAM184A FAM47B FAM90A1 FANCM FCHSD1 GTSF1 HIF1A HSPD1 ITGB3BP JHY KCTD18 KDM4D KLC2 L3MBTL3 LARP4 LARP7 LATS1 LGALS8 LINC01139 LRP6 MAP1B MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPT MATK MBP MLLT3 MRGBP MRPL19 MRPL28 MTA1 MYL9 NCBP3 NDUFAF7 NEK1 NSL1 PADI4 PDCL PHF20L1 PIK3CB PIK3R1 PLK1 POLR2M POU5F1 PPP1R8 PRICKLE1 PRKCZ PSME3IP1 PTPN23 RAB11FIP2 RAD51AP1 RALYL RAPGEF4 RASL11B RBIS RHBDD1 RIPK2 RIT1 RPAP3 RPS6KB2 SCEL SERF1A SH3GL2 SH3GL3 SKA3 SMTNL2 SPATS2 SQSTM1 STAC STK24 STK25 STK3 STK40 STN1 STRBP STUB1 SUPT4H1 SYNJ1 TAOK3 TAS2R60 TBC1D22B TCEA2 TCP10L TGIF2LX TRAF2 TTC27 TTLL1 TUBA1A UBXN10 UFD1 UQCRB USP39 VASH2 VGLL4 VN1R1 WSB1 WT1-AS XIRP2 ZAP70 ZFAND5 ZMYM5 ZRANB2
Entrez ID		60	120892
HPRD ID		00032	10613
Ensembl ID		ENSG00000075624	ENSG00000188906
Uniprot IDs		P60709 Q1KLZ0	Q17RV3 Q5S007
PDB IDs		3BYH 3D2U 3J82 3LUE 6ANU 6ICT 6ICV 6LTJ 6MBJ 6MBK 6MBL 6NBW 6OX0 6OX1 6OX2 6OX3 6OX4 6OX5 6V62 6V63 6WK1 6WK2 7AS4	2ZEJ 3D6T 5MY9 5MYC 6DLO 6DLP 6OJE 6OJF 6VNO 6VP6 6VP7 6XR4
Enriched GO Terms of Interacting Partners?
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