BBS4 and SEMA7A

		BBS4	SEMA7A
Description		Bardet-Biedl syndrome 4	semaphorin 7A (John Milton Hagen blood group)
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GO Annotations	Cellular Component	Pericentriolar Material Nucleus Centrosome Centriole Cytosol Cilium Motile Cilium Centriolar Satellite BBSome Ciliary Transition Zone Ciliary Basal Body Ciliary Membrane Non-motile Cilium	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane Anchored Component Of Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Dynactin Binding Alpha-tubulin Binding Beta-tubulin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Integrin Binding Protein Binding Semaphorin Receptor Binding Chemorepellent Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cytokinesis Neural Tube Closure Retina Homeostasis Heart Looping Centrosome Cycle Spermatid Development Visual Perception Sensory Perception Of Smell Protein Transport Dendrite Development Regulation Of Lipid Metabolic Process Striatum Development Hippocampus Development Cerebral Cortex Development Adult Behavior Melanosome Transport Regulation Of Cytokinesis Protein Localization To Organelle Microtubule Anchoring At Centrosome Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Fat Cell Differentiation Photoreceptor Cell Maintenance Positive Regulation Of Cilium Assembly Retinal Rod Cell Development Intracellular Transport Brain Morphogenesis Sensory Processing Maintenance Of Protein Location In Nucleus Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Protein Localization To Cilium Protein Localization To Centrosome Non-motile Cilium Assembly	Osteoblast Differentiation Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Axon Guidance Olfactory Lobe Development Positive Regulation Of Cell Migration Positive Regulation Of Axon Extension Axon Extension Negative Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Inflammatory Response Negative Chemotaxis Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway
Pathways		BBSome-mediated cargo-targeting to cilium	Other semaphorin interactions Other semaphorin interactions
Drugs
Diseases
GWAS		Body mass index ( 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Theory of mind score in adolescence (Emotional Triangles Task) ( 29472613) Triglycerides ( 30275531) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Airflow obstruction ( 22837378) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein A1 levels ( 32203549) Craniofacial microsomia ( 26853712) HDL cholesterol levels ( 32203549) Hypertension ( 31879980)
Interacting Genes		26 interacting genes: AAGAB ACTB ANP32A BHMT C2CD6 CALCA DCTN1 EEF1A1 EIF3A EPAS1 EXOC7 FHOD1 HSCB IGDCC3 KRT18 MRPL28 MYOG OAS1 PAX2 PCM1 RARA RARG REL SEMA7A SPIRE1 ZIC1	4 interacting genes: BBS4 CHRNA5 CSF2 PLXNC1
Entrez ID		585	8482
HPRD ID		08982	07081
Ensembl ID		ENSG00000140463	ENSG00000138623
Uniprot IDs		A0A0S2Z3A9 Q96RK4	B3KMH6 F5GYX3 O75326
PDB IDs		6XT9	3NVQ
Enriched GO Terms of Interacting Partners?
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