SEMA7A and PLXNC1

Number of citations of the paper that reports this interaction (PubMedID 10520995)
323

Data Source:
HPRD (in vivo, in vitro)

		SEMA7A	PLXNC1
Description		semaphorin 7A (John Milton Hagen blood group)	plexin C1
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane Anchored Component Of Membrane Collagen-containing Extracellular Matrix	Semaphorin Receptor Complex Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Integrin Binding Protein Binding Semaphorin Receptor Binding Chemorepellent Activity	Signaling Receptor Binding Protein Binding Semaphorin Receptor Activity
	Biological Process	Osteoblast Differentiation Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Axon Guidance Olfactory Lobe Development Positive Regulation Of Cell Migration Positive Regulation Of Axon Extension Axon Extension Negative Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Inflammatory Response Negative Chemotaxis Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway	Cell Adhesion Negative Regulation Of Cell Adhesion Regulation Of Cell Shape Regulation Of Cell Migration Regulation Of GTPase Activity Positive Regulation Of Axonogenesis Semaphorin-plexin Signaling Pathway Involved In Axon Guidance
Pathways		Other semaphorin interactions Other semaphorin interactions	Other semaphorin interactions
Drugs
Diseases
GWAS		Airflow obstruction ( 22837378) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein A1 levels ( 32203549) Craniofacial microsomia ( 26853712) HDL cholesterol levels ( 32203549) Hypertension ( 31879980)	Alopecia areata ( 25608926) Asthma ( 31959851 34103634 32296059) Blood protein levels ( 30072576 29875488 28240269) Diastolic blood pressure ( 30578418) Major depressive disorder ( 29317602) Multiple sclerosis ( 31604244) Pulse pressure ( 30578418) Remission after SSRI treatment in MDD or neuroticism ( 29559929) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Response to ranibizumab in age-related macular degeneration (exudative) ( 30054556)
Interacting Genes		4 interacting genes: BBS4 CHRNA5 CSF2 PLXNC1	2 interacting genes: CKAP4 SEMA7A
Entrez ID		8482	10154
HPRD ID		07081	05036
Ensembl ID		ENSG00000138623	ENSG00000136040
Uniprot IDs		B3KMH6 F5GYX3 O75326	O60486
PDB IDs		3NVQ	3KUZ 3NVN 3NVQ 6VXK
Enriched GO Terms of Interacting Partners?
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