BBS4 and OAS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		BBS4	OAS1
Description		Bardet-Biedl syndrome 4	2'-5'-oligoadenylate synthetase 1
Image
GO Annotations	Cellular Component	Pericentriolar Material Nucleus Centrosome Centriole Cytosol Cilium Motile Cilium Centriolar Satellite BBSome Ciliary Transition Zone Ciliary Basal Body Ciliary Membrane Non-motile Cilium	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Membrane
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Dynactin Binding Alpha-tubulin Binding Beta-tubulin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	2'-5'-oligoadenylate Synthetase Activity Double-stranded RNA Binding Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cytokinesis Neural Tube Closure Retina Homeostasis Heart Looping Centrosome Cycle Spermatid Development Visual Perception Sensory Perception Of Smell Protein Transport Dendrite Development Regulation Of Lipid Metabolic Process Striatum Development Hippocampus Development Cerebral Cortex Development Adult Behavior Melanosome Transport Regulation Of Cytokinesis Protein Localization To Organelle Microtubule Anchoring At Centrosome Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Fat Cell Differentiation Photoreceptor Cell Maintenance Positive Regulation Of Cilium Assembly Retinal Rod Cell Development Intracellular Transport Brain Morphogenesis Sensory Processing Maintenance Of Protein Location In Nucleus Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Protein Localization To Cilium Protein Localization To Centrosome Non-motile Cilium Assembly	Glucose Metabolic Process Response To Virus Positive Regulation Of Interferon-beta Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Interferon-beta Glucose Homeostasis Defense Response To Bacterium Surfactant Homeostasis Negative Regulation Of Viral Genome Replication Defense Response To Virus Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Ribonuclease Activity Interleukin-27-mediated Signaling Pathway Positive Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of IP-10 Production Cellular Response To Virus Antiviral Innate Immune Response Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		BBSome-mediated cargo-targeting to cilium	Interferon gamma signaling OAS antiviral response Interferon alpha/beta signaling
Drugs			Cysteine-S-acetamide
Diseases
GWAS		Body mass index ( 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Theory of mind score in adolescence (Emotional Triangles Task) ( 29472613) Triglycerides ( 30275531) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Blood protein levels ( 30072576 29875488) Body mass index ( 26426971) Glycemic traits ( 23575436) Low HDL-cholesterol levels ( 31006500) Response to fenofibrate (adiponectin levels) ( 23149075) Right-sided colonic diverticulosis ( 31089239) Urate levels ( 31578528)
Interacting Genes		26 interacting genes: AAGAB ACTB ANP32A BHMT C2CD6 CALCA DCTN1 EEF1A1 EIF3A EPAS1 EXOC7 FHOD1 HSCB IGDCC3 KRT18 MRPL28 MYOG OAS1 PAX2 PCM1 RARA RARG REL SEMA7A SPIRE1 ZIC1	11 interacting genes: ACTN1 BBS4 BUD23 COG6 EXOC5 GOLGA2 HOOK2 PRMT6 RPL30 RUFY1 TRIM27
Entrez ID		585	4938
HPRD ID		08982	08879
Ensembl ID		ENSG00000140463	ENSG00000089127
Uniprot IDs		A0A0S2Z3A9 Q96RK4	P00973
PDB IDs		6XT9	4IG8
Enriched GO Terms of Interacting Partners?
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