PTPRC and IFNAR1

Number of citations of the paper that reports this interaction (PubMedID 9403695)
34

Data Source:
HPRD (in vivo, in vitro)

		PTPRC	IFNAR1
Description		protein tyrosine phosphatase receptor type C	interferon alpha and beta receptor subunit 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Secretory Granule Membrane Bleb Membrane Raft Extracellular Exosome Membrane Microdomain	Lysosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Signaling Receptor Binding Protein Binding Heparin Binding Protein Kinase Binding Ankyrin Binding Spectrin Binding Heparan Sulfate Proteoglycan Binding	Cytokine Receptor Activity Type I Interferon Receptor Activity Protein Binding Type I Interferon Binding
	Biological Process	Natural Killer Cell Differentiation Negative Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Cytokine-mediated Signaling Pathway Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Immunoglobulin Production Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Response To Gamma Radiation Regulation Of Gene Expression Dephosphorylation B Cell Differentiation T Cell Differentiation Positive Regulation Of B Cell Proliferation Cellular Response To Extracellular Stimulus Negative Regulation Of Protein Autophosphorylation Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Peptidyl-tyrosine Dephosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source T Cell Proliferation B Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Positive Regulation Of MAPK Cascade Cell Cycle Phase Transition Plasma Membrane Raft Distribution Positive Thymic T Cell Selection Negative Thymic T Cell Selection Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Protein Kinase Activity Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Stem Cell Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Phagocytosis T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Regulation Of Cell Cycle Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Tyrosine Phosphatase Activity Negative Regulation Of Microglial Cell Activation DN2 Thymocyte Differentiation Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Receptor Signaling Pathway Via JAK-STAT Response To Virus Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interferon-alpha Type I Interferon Signaling Pathway Positive Regulation Of Cellular Respiration
Pathways		Phosphorylation of CD3 and TCR zeta chains Other semaphorin interactions Neutrophil degranulation	Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling Potential therapeutics for SARS
Drugs			Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Interferon alfa Human interferon omega-1 Human interferon beta
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Asthma ( 31959851 30929738 34103634 32296059 31619474) Asthma (adult onset) ( 30929738) Celiac disease and Rheumatoid arthritis ( 26546613) Crohn's disease ( 26192919 28067908) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 26192919) LDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 20139978 28017375) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Monocyte percentage of white cells ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 29403010 32888494) Refractive error ( 32231278) Rheumatoid arthritis (ACPA-positive) ( 24532676) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 33272962) Type 1 diabetes ( 34012112) Ulcerative colitis ( 24837172) Vitiligo ( 27723757) White blood cell count ( 32888494)	Blood protein levels ( 30072576 29875488) Crohn's disease ( 23128233) Psoriasis ( 25903422)
Interacting Genes		58 interacting genes: ANP32A CD1D CD2 CD22 CD247 CD28 CD4 CD79A CD8A CDK18 CHIT1 CRB1 CSNK1E CSNK2A1 CSNK2A2 CXCR4 DPP4 EIF2D EZR F13B FCGR3A FYN GANAB GRB2 GRB7 IFNAR1 IL10 INSR IRS1 ITGAL JAK1 JAK2 JAK3 LCK LCP2 LGALS1 LSM1 LYN MAPK1 MBL2 MYOG PAEP PAICS PPFIA1 PPFIBP2 PRKCSH PTPN6 PTPRCAP RASA1 RNF11 SEMA4D SKAP1 SRC TYK2 UHRF2 VAV1 VBP1 ZAP70	26 interacting genes: BRCC3 CRKL FBXW11 GART IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LAPTM4B LCK MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC RACK1 SOCS1 STAT2 STAT3 TYK2 USP7 ZAP70
Entrez ID		5788	3454
HPRD ID		01050	00126
Ensembl ID		ENSG00000081237	ENSG00000142166
Uniprot IDs		M9MML4 P08575	A0A494C0E2 P17181
PDB IDs		1YGR 1YGU 5FMV 5FN6 5FN7	3S98 3SE3 3SE4 4PO6
Enriched GO Terms of Interacting Partners?
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