IFNAR1 and IFNB1

Number of citations of the paper that reports this interaction (PubMedID 1834641)
8

Data Source:
HPRD (in vivo)

		IFNAR1	IFNB1
Description		interferon alpha and beta receptor subunit 1	interferon beta 1
Image
GO Annotations	Cellular Component	Lysosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Receptor Activity Type I Interferon Receptor Activity Protein Binding Type I Interferon Binding	Cytokine Activity Type I Interferon Receptor Binding Protein Binding Chloramphenicol O-acetyltransferase Activity
	Biological Process	Receptor Signaling Pathway Via JAK-STAT Response To Virus Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interferon-alpha Type I Interferon Signaling Pathway Positive Regulation Of Cellular Respiration	Adaptive Immune Response T Cell Activation Involved In Immune Response B Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Response To Virus Cytokine-mediated Signaling Pathway Natural Killer Cell Activation B Cell Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Cellular Response To Interferon-beta B Cell Proliferation Response To Exogenous DsRNA Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Type I Interferon Signaling Pathway Cellular Response To Exogenous DsRNA Cellular Response To Virus Negative Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling Potential therapeutics for SARS	Oxidative Stress Induced Senescence Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Factors involved in megakaryocyte development and platelet production
Drugs		Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Interferon alfa Human interferon omega-1 Human interferon beta	Beta-D-Glucose
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Crohn's disease ( 23128233) Psoriasis ( 25903422)	Axial length ( 24144296)
Interacting Genes		26 interacting genes: BRCC3 CRKL FBXW11 GART IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LAPTM4B LCK MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC RACK1 SOCS1 STAT2 STAT3 TYK2 USP7 ZAP70	3 interacting genes: IFNAR1 IFNAR2 PEX19
Entrez ID		3454	3456
HPRD ID		00126	00972
Ensembl ID		ENSG00000142166	ENSG00000171855
Uniprot IDs		A0A494C0E2 P17181	P01574
PDB IDs		3S98 3SE3 3SE4 4PO6	1AU1
Enriched GO Terms of Interacting Partners?
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