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PTPRC and SEMA4D
Number of citations of the paper that reports this interaction (PubMedID
11254687
)
50
Data Source:
HPRD
(in vivo, in vitro)
PTPRC
SEMA4D
Description
protein tyrosine phosphatase receptor type C
semaphorin 4D
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
External Side Of Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Cell Surface
Membrane
Integral Component Of Membrane
Secretory Granule Membrane
Bleb
Membrane Raft
Extracellular Exosome
Membrane Microdomain
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Molecular Function
Protein Tyrosine Phosphatase Activity
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Signaling Receptor Binding
Protein Binding
Heparin Binding
Protein Kinase Binding
Ankyrin Binding
Spectrin Binding
Heparan Sulfate Proteoglycan Binding
Transmembrane Signaling Receptor Activity
Signaling Receptor Binding
Protein Binding
Semaphorin Receptor Binding
Signaling Receptor Activity
Chemorepellent Activity
Biological Process
Natural Killer Cell Differentiation
Negative Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of T Cell Mediated Cytotoxicity
Negative Regulation Of Cytokine-mediated Signaling Pathway
Hematopoietic Progenitor Cell Differentiation
Positive Regulation Of Immunoglobulin Production
Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Negative Regulation Of Protein Kinase Activity
Protein Dephosphorylation
Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration
Leukocyte Cell-cell Adhesion
Cell Surface Receptor Signaling Pathway
Response To Gamma Radiation
Regulation Of Gene Expression
Dephosphorylation
B Cell Differentiation
T Cell Differentiation
Positive Regulation Of B Cell Proliferation
Cellular Response To Extracellular Stimulus
Negative Regulation Of Protein Autophosphorylation
Regulation Of Interleukin-8 Production
Negative Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Tumor Necrosis Factor Production
Heterotypic Cell-cell Adhesion
Peptidyl-tyrosine Dephosphorylation
Calcium-mediated Signaling Using Intracellular Calcium Source
T Cell Proliferation
B Cell Proliferation
Positive Regulation Of T Cell Proliferation
T Cell Activation
Positive Regulation Of MAPK Cascade
Cell Cycle Phase Transition
Plasma Membrane Raft Distribution
Positive Thymic T Cell Selection
Negative Thymic T Cell Selection
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Protein Kinase Activity
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Alpha-beta T Cell Proliferation
Positive Regulation Of Isotype Switching To IgG Isotypes
Bone Marrow Development
Stem Cell Development
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Phagocytosis
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Positive Regulation Of Antigen Receptor-mediated Signaling Pathway
Release Of Sequestered Calcium Ion Into Cytosol
Defense Response To Virus
Regulation Of Cell Cycle
Regulation Of Protein Tyrosine Kinase Activity
Negative Regulation Of Protein Tyrosine Kinase Activity
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Protein Tyrosine Phosphatase Activity
Negative Regulation Of Microglial Cell Activation
DN2 Thymocyte Differentiation
Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of Hematopoietic Stem Cell Migration
Positive Regulation Of Stem Cell Proliferation
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Neural Crest Cell Migration
Positive Regulation Of Protein Phosphorylation
Immune Response
Cell Adhesion
Negative Regulation Of Cell Adhesion
Axon Guidance
Regulation Of Cell Shape
Negative Regulation Of Alkaline Phosphatase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Cell Migration
Regulation Of Cell Projection Organization
Negative Regulation Of Apoptotic Process
Positive Regulation Of GTPase Activity
Ossification Involved In Bone Maturation
Negative Regulation Of Osteoblast Differentiation
Positive Regulation Of Collateral Sprouting
Regulation Of Dendrite Morphogenesis
Negative Regulation Of Axon Extension Involved In Axon Guidance
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
Negative Chemotaxis
Leukocyte Aggregation
Semaphorin-plexin Signaling Pathway
Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis
Positive Regulation Of Inhibitory Synapse Assembly
Pathways
Phosphorylation of CD3 and TCR zeta chains
Other semaphorin interactions
Neutrophil degranulation
Sema4D mediated inhibition of cell attachment and migration
Sema4D induced cell migration and growth-cone collapse
Other semaphorin interactions
Drugs
Diseases
GWAS
Apolipoprotein B levels (
32203549
)
Aspartate aminotransferase levels (
33547301
)
Asthma (
31959851
30929738
34103634
32296059
31619474
)
Asthma (adult onset) (
30929738
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Crohn's disease (
26192919
28067908
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Inflammatory bowel disease (
26192919
)
LDL cholesterol levels (
32203549
)
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
)
Mean corpuscular hemoglobin (
29403010
20139978
28017375
)
Mean corpuscular hemoglobin concentration (
29403010
)
Mean corpuscular volume (
29403010
32888494
)
Mean platelet volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (adrenergics, inhalants) (
31015401
)
Monocyte percentage of white cells (
32888494
)
Plateletcrit (
32888494
)
Red blood cell count (
29403010
32888494
)
Refractive error (
32231278
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Sum eosinophil basophil counts (
27863252
)
Systemic lupus erythematosus (
27399966
33272962
)
Type 1 diabetes (
34012112
)
Ulcerative colitis (
24837172
)
Vitiligo (
27723757
)
White blood cell count (
32888494
)
Blood protein levels (
30072576
29875488
)
Body mass index (
28296344
)
Brain morphology (MOSTest) (
32665545
)
High light scatter reticulocyte count (
32888494
27863252
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Mean spheric corpuscular volume (
32888494
)
Refractive error (
32231278
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Youthful appearance (self-reported) (
32339537
)
Interacting Genes
58 interacting genes:
ANP32A
CD1D
CD2
CD22
CD247
CD28
CD4
CD79A
CD8A
CDK18
CHIT1
CRB1
CSNK1E
CSNK2A1
CSNK2A2
CXCR4
DPP4
EIF2D
EZR
F13B
FCGR3A
FYN
GANAB
GRB2
GRB7
IFNAR1
IL10
INSR
IRS1
ITGAL
JAK1
JAK2
JAK3
LCK
LCP2
LGALS1
LSM1
LYN
MAPK1
MBL2
MYOG
PAEP
PAICS
PPFIA1
PPFIBP2
PRKCSH
PTPN6
PTPRCAP
RASA1
RNF11
SEMA4D
SKAP1
SRC
TYK2
UHRF2
VAV1
VBP1
ZAP70
5 interacting genes:
CD72
CRK
LINC00839
PLXNB1
PTPRC
Entrez ID
5788
10507
HPRD ID
01050
03520
Ensembl ID
ENSG00000081237
ENSG00000187764
Uniprot IDs
M9MML4
P08575
Q92854
PDB IDs
1YGR
1YGU
5FMV
5FN6
5FN7
1OLZ
3OL2
Enriched GO Terms of Interacting Partners
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