SLAMF7 and TRIB2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		SLAMF7	TRIB2
Description		SLAM family member 7	tribbles pseudokinase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Nucleus Cytoplasm Cytoskeleton
	Molecular Function	Identical Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Kinase Inhibitor Activity Protein Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity
	Biological Process	Adaptive Immune Response Cell Adhesion Natural Killer Cell Activation T Cell Activation Natural Killer Cell Mediated Cytotoxicity	Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interleukin-10 Production Regulation Of MAP Kinase Activity Negative Regulation Of Fat Cell Differentiation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		Elotuzumab
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) IgM levels ( 28628107) Inflammatory bowel disease ( 23128233) Microalbuminuria ( 26631737) Multiple sclerosis ( 24076602)	Age at first birth ( 34211149) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Cataracts ( 34127677) Chronotype ( 30696823) Dental caries ( 23064961) Diffusing capacity of carbon monoxide ( 30694715) Diisocyanate-induced asthma ( 25918132) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Graves' disease ( 22922229) Heel bone mineral density ( 30598549) joint destruction in rheumatoid arthritis (rapid vs slow) ( 33585033) Methadone dose in opioid dependence ( 28115739) Multiple sclerosis ( 24076602) Optic cup area ( 25631615 28073927) Pericardial adipose tissue adjusted for height and weight ( 27918534) Pericardial fat ( 22589742 27918534) Platelet count ( 32888494)
Interacting Genes		11 interacting genes: ADRA2A API5 CLK3 MAK PANK1 PITX2 SH2D1A SVIL THRSP TMOD4 TRIB2	6 interacting genes: APP BTRC PARVG PRMT6 SLAMF7 UBQLN4
Entrez ID		57823	28951
HPRD ID		09432	18224
Ensembl ID		ENSG00000026751	ENSG00000071575
Uniprot IDs		B4DVL7 B4DW98 Q9NQ25	Q92519
PDB IDs
Enriched GO Terms of Interacting Partners?
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