TRIB2 and SLAMF7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		TRIB2	SLAMF7
Description		tribbles pseudokinase 2	SLAM family member 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Kinase Inhibitor Activity Protein Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity	Identical Protein Binding
	Biological Process	Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interleukin-10 Production Regulation Of MAP Kinase Activity Negative Regulation Of Fat Cell Differentiation	Adaptive Immune Response Cell Adhesion Natural Killer Cell Activation T Cell Activation Natural Killer Cell Mediated Cytotoxicity
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs			Elotuzumab
Diseases
GWAS		Age at first birth ( 34211149) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Cataracts ( 34127677) Chronotype ( 30696823) Dental caries ( 23064961) Diffusing capacity of carbon monoxide ( 30694715) Diisocyanate-induced asthma ( 25918132) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Graves' disease ( 22922229) Heel bone mineral density ( 30598549) joint destruction in rheumatoid arthritis (rapid vs slow) ( 33585033) Methadone dose in opioid dependence ( 28115739) Multiple sclerosis ( 24076602) Optic cup area ( 25631615 28073927) Pericardial adipose tissue adjusted for height and weight ( 27918534) Pericardial fat ( 22589742 27918534) Platelet count ( 32888494)	Blood protein levels ( 30072576 29875488 28240269) IgM levels ( 28628107) Inflammatory bowel disease ( 23128233) Microalbuminuria ( 26631737) Multiple sclerosis ( 24076602)
Interacting Genes		6 interacting genes: APP BTRC PARVG PRMT6 SLAMF7 UBQLN4	11 interacting genes: ADRA2A API5 CLK3 MAK PANK1 PITX2 SH2D1A SVIL THRSP TMOD4 TRIB2
Entrez ID		28951	57823
HPRD ID		18224	09432
Ensembl ID		ENSG00000071575	ENSG00000026751
Uniprot IDs		Q92519	B4DVL7 B4DW98 Q9NQ25
PDB IDs
Enriched GO Terms of Interacting Partners?
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