HOMEZ and CCNK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HOMEZ	CCNK
Description		homeobox and leucine zipper encoding	cyclin K
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytosol	Cyclin K-CDK12 Complex Cyclin K-CDK13 Complex Nucleus Nucleoplasm Cyclin/CDK Positive Transcription Elongation Factor Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Cycle Positive Regulation Of DNA-templated Transcription, Elongation Negative Regulation By Host Of Viral Genome Replication Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division Positive Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Serine 2 Residues
Pathways			Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat HIV elongation arrest and recovery Pausing and recovery of HIV elongation SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Height ( 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Mean platelet volume ( 32888494) Pulse pressure ( 27841878) Reticulocyte count ( 32888494) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure ( 27841878)	Scalp hair shape ( 26926045) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		114 interacting genes: ACTR10 AEN ANKRD11 ANKRD2 ARHGAP9 ASB6 AXIN1 BIVM BYSL C2orf42 CBX8 CCDC13 CCDC187 CCHCR1 CCNK CDC7 CENPS CENPS-CORT CFAP206 CTNNA3 DEF6 DGCR6 DHX16 DNTTIP1 EBF1 EIF4E2 ELOA ENKD1 FAM90A1 FARS2 GAS8 GFAP GPANK1 GRB2 HOXC8 HSF2BP IL16 INO80B JAKMIP2 KIFC3 KPNA2 LENG1 LGALS4 LMO1 LMO3 LNX1 LRRC7 LSM4 MAD2L1BP MAFG MAPK1 MED18 MORF4L2 MOS MRPL11 NCK1 NCK2 NEIL2 NEK6 NXF1 OSGIN1 PARVG PHF1 PHF19 PIBF1 PIN1 PLEKHA7 POLDIP3 PRKAA1 PRKAA2 PRPF18 PSMA1 RASL10A RBM39 RNF8 RPGR RPL9 RPP25 RPS25 SCNM1 SDCBP SEC23A SH3RF2 SMARCB1 SMARCD1 SMYD1 SNRPB2 SUMO2 SUMO3 TARS2 TBC1D30 TCEA2 TCEANC TEAD4 TLE5 TRAF4 TSGA10IP TXK USF1 VEZF1 VPS9D1 ZBTB25 ZBTB7A ZMYND19 ZNF165 ZNF250 ZNF280C ZNF35 ZNF417 ZNF580 ZNF629 ZNF688 ZNF76 ZSCAN5B	54 interacting genes: ATXN1 BHLHE40 CCDC85B CDK18 CDK2 CDK9 CEP76 CYSRT1 DDB1 DDIT4L DVL3 EFEMP2 FAM168B FKBP6 HIVEP1 HMG20A HNRNPH1 HNRNPH2 HOMEZ HOXA1 HSFY1 HSFY2 KCNRG KRTAP13-2 KRTAP19-6 KRTAP19-7 KRTAP4-12 KRTAP6-2 KRTAP8-1 LZTS2 MYCL NDC80 NECAB2 OXER1 PIN1 POLR1C POLR2A POU6F2 PRR20A PRR20B PRR20C PRR20D PRR20E RBPMS RBX1 RFX6 RHOXF2 RUNX1 STX11 TLE5 TSC22D4 USHBP1 USP54 ZNF446
Entrez ID		57594	8812
HPRD ID		12167	10352
Ensembl ID		ENSG00000215271	ENSG00000090061
Uniprot IDs		Q8IX15	A0A024R6K1 O75909
PDB IDs		2ECC 2YS9	2I53 4CXA 4NST 4UN0 5ACB 5EFQ 6B3E 6CKX 6TD3
Enriched GO Terms of Interacting Partners?
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