HOMEZ and NEIL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HOMEZ	NEIL2
Description		homeobox and leucine zipper encoding	nei like DNA glycosylase 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytosol	Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle Mitotic Spindle
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding	Damaged DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding Microtubule Binding Zinc Ion Binding DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Base-excision Repair Depyrimidination
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs			Iron Copper Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases
GWAS		Height ( 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Mean platelet volume ( 32888494) Pulse pressure ( 27841878) Reticulocyte count ( 32888494) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure ( 27841878)	Alcohol dependence ( 23942779) Apolipoprotein A1 levels ( 32203549) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) Medication use (calcium channel blockers) ( 31015401) Neutrophil count ( 21507922) Nicotine use ( 23942779) Polycystic ovary syndrome ( 26284813) Processed meat consumption ( 32066663) Systolic blood pressure ( 32902719) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		114 interacting genes: ACTR10 AEN ANKRD11 ANKRD2 ARHGAP9 ASB6 AXIN1 BIVM BYSL C2orf42 CBX8 CCDC13 CCDC187 CCHCR1 CCNK CDC7 CENPS CENPS-CORT CFAP206 CTNNA3 DEF6 DGCR6 DHX16 DNTTIP1 EBF1 EIF4E2 ELOA ENKD1 FAM90A1 FARS2 GAS8 GFAP GPANK1 GRB2 HOXC8 HSF2BP IL16 INO80B JAKMIP2 KIFC3 KPNA2 LENG1 LGALS4 LMO1 LMO3 LNX1 LRRC7 LSM4 MAD2L1BP MAFG MAPK1 MED18 MORF4L2 MOS MRPL11 NCK1 NCK2 NEIL2 NEK6 NXF1 OSGIN1 PARVG PHF1 PHF19 PIBF1 PIN1 PLEKHA7 POLDIP3 PRKAA1 PRKAA2 PRPF18 PSMA1 RASL10A RBM39 RNF8 RPGR RPL9 RPP25 RPS25 SCNM1 SDCBP SEC23A SH3RF2 SMARCB1 SMARCD1 SMYD1 SNRPB2 SUMO2 SUMO3 TARS2 TBC1D30 TCEA2 TCEANC TEAD4 TLE5 TRAF4 TSGA10IP TXK USF1 VEZF1 VPS9D1 ZBTB25 ZBTB7A ZMYND19 ZNF165 ZNF250 ZNF280C ZNF35 ZNF417 ZNF580 ZNF629 ZNF688 ZNF76 ZSCAN5B	10 interacting genes: CDHR3 CRX EP300 HOMEZ INCA1 LCN2 MEOX1 PAX5 REL TRIM27
Entrez ID		57594	252969
HPRD ID		12167	16406
Ensembl ID		ENSG00000215271	ENSG00000154328
Uniprot IDs		Q8IX15	A0A024R361 Q969S2
PDB IDs		2ECC 2YS9	1VZP
Enriched GO Terms of Interacting Partners?
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