PTGIR and TBXA2R

Number of citations of the paper that reports this interaction (PubMedID 20522800)
14

Data Source:
BioGRID (fluorescent resonance energy transfer, fluorescent resonance energy transfer)

		PTGIR	TBXA2R
Description		prostaglandin I2 receptor	thromboxane A2 receptor
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane	Acrosomal Vesicle Plasma Membrane Integral Component Of Plasma Membrane Nuclear Speck
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Prostacyclin Receptor Activity	Thromboxane A2 Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Catalytic Activity	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Response To Xenobiotic Stimulus Second-messenger-mediated Signaling Positive Regulation Of Blood Coagulation Response To Testosterone Thromboxane A2 Signaling Pathway Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Regulation Of Catalytic Activity Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways		Prostanoid ligand receptors Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Prostanoid ligand receptors G alpha (q) signalling events G alpha (12/13) signalling events Thromboxane signalling through TP receptor
Drugs		Treprostinil Iloprost Dinoprost tromethamine Epoprostenol Beraprost Selexipag	Ridogrel Seratrodast Morniflumate
Diseases
GWAS		Crohn's disease ( 28067908)
Interacting Genes		10 interacting genes: ADCY10 GNA11 GNAQ GNAS LNX1 PDE6D PDZD3 PRKCA RAB11A TBXA2R	35 interacting genes: ADIPOR1 ARL6IP6 C5orf46 EMP1 GJB2 GNA11 GNA12 GNA13 GNAI2 GNAQ GNAS GNB1 GNG2 GPRASP1 GRK5 GRK6 MFSD5 MS4A13 NME2 NOX1 PRDX4 PRKCA PSMA7 PSME3 PTGIR RAB11A RACK1 RAF1 RPGRIP1L SLC35B4 SLC41A1 TM4SF4 VRK2 YWHAZ ZDHHC15
Entrez ID		5739	6915
HPRD ID		08959	01768
Ensembl ID		ENSG00000160013	ENSG00000006638
Uniprot IDs		P43119	P21731 Q05C92 Q0VAB0
PDB IDs			1LBN
Enriched GO Terms of Interacting Partners?
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