PTGIR and GNA11

Number of citations of the paper that reports this interaction (PubMedID 10446129)
18

Data Source:
HPRD (in vitro)

		PTGIR	GNA11
Description		prostaglandin I2 receptor	G protein subunit alpha 11
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane	Photoreceptor Outer Segment Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Synapse Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Prostacyclin Receptor Activity	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Catalytic Activity	Skeletal System Development Action Potential Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Heart Development Phototransduction, Visible Light Entrainment Of Circadian Clock Regulation Of Melanocyte Differentiation Developmental Pigmentation Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To PH
Pathways		Prostanoid ligand receptors Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs		Treprostinil Iloprost Dinoprost tromethamine Epoprostenol Beraprost Selexipag
Diseases
GWAS		Crohn's disease ( 28067908)	Asthma ( 31959851)
Interacting Genes		10 interacting genes: ADCY10 GNA11 GNAQ GNAS LNX1 PDE6D PDZD3 PRKCA RAB11A TBXA2R	17 interacting genes: ADRA1B ADRB2 BDKRB2 CHRM2 EDNRA EDNRB HTR2A HTR2B KDR MTNR1A PTGIR RGS14 RGS3 SLC9A3R1 TBXA2R TRPC3 TSHR
Entrez ID		5739	2767
HPRD ID		08959	00759
Ensembl ID		ENSG00000160013	ENSG00000088256
Uniprot IDs		P43119	P29992
PDB IDs			6OIJ
Enriched GO Terms of Interacting Partners?
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