PTGIR and GNAQ

Number of citations of the paper that reports this interaction (PubMedID 11443126)
25

Data Source:
HPRD (in vitro, in vivo)

		PTGIR	GNAQ
Description		prostaglandin I2 receptor	G protein subunit alpha q
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane	Photoreceptor Outer Segment Cytoplasm Lysosomal Membrane Golgi Apparatus Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Synapse Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Prostacyclin Receptor Activity	G Protein-coupled Receptor Binding GTPase Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Catalytic Activity	Action Potential Negative Regulation Of Protein Kinase Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Blood Coagulation Phototransduction, Visible Light Entrainment Of Circadian Clock Protein Stabilization Regulation Of Canonical Wnt Signaling Pathway
Pathways		Prostanoid ligand receptors Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs		Treprostinil Iloprost Dinoprost tromethamine Epoprostenol Beraprost Selexipag
Diseases
GWAS		Crohn's disease ( 28067908)	Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		10 interacting genes: ADCY10 GNA11 GNAQ GNAS LNX1 PDE6D PDZD3 PRKCA RAB11A TBXA2R	48 interacting genes: ADHFE1 ADRA1B AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRK2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1
Entrez ID		5739	2776
HPRD ID		08959	02998
Ensembl ID		ENSG00000160013	ENSG00000156052
Uniprot IDs		P43119	A0A024R240 P50148
PDB IDs			6VU5
Enriched GO Terms of Interacting Partners?
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