PTGFR and PTPRT

		PTGFR	PTPRT
Description		prostaglandin F receptor	protein tyrosine phosphatase receptor type T
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Prostaglandin F Receptor Activity	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding Protein Phosphatase Binding Protein Homodimerization Activity Alpha-catenin Binding Gamma-catenin Binding Cadherin Binding Delta-catenin Binding STAT Family Protein Binding
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Parturition Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Response To Estradiol Response To Lipopolysaccharide Calcium-mediated Signaling Using Intracellular Calcium Source Negative Regulation Of Apoptotic Process Cellular Response To Prostaglandin D Stimulus	Protein Dephosphorylation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Cellular Response To Interleukin-6 Negative Regulation Of Receptor Signaling Pathway Via STAT Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity
Pathways		Prostanoid ligand receptors G alpha (q) signalling events
Drugs		Travoprost Latanoprost Bimatoprost Dinoprost tromethamine Tafluprost Latanoprostene bunod
Diseases
GWAS		Bipolar disorder ( 22182935) Depression in multiple sclerosis (post-diagnosis) ( 33296963) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Skin fluorescence in type 1 diabetes ( 27207532) Systolic blood pressure (alcohol consumption interaction) ( 24376456)	Age-related nuclear cataracts ( 24951543) Anxiety and stress-related disorders ( 31116379) BMI x SSRI levels interaction in schizophrenia or bipolar disorder ( 33824429) Diastolic blood pressure ( 27841878) Diisocyanate-induced asthma ( 25918132) Eye morphology ( 29921221) Facial attractiveness (male raters) ( 30946739) Fractional exhaled nitric oxide (childhood) ( 24315451) Gastroesophageal reflux disease ( 34187846) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels in HIV infection ( 33109212) Hip circumference ( 28552196) Household income (MTAG) ( 31844048) Metabolite levels ( 23823483) Microalbuminuria ( 26631737) Periodontitis (Mean PAL) ( 24024966) Problematic alcohol use in trauma-exposed individuals ( 29082582) Recurrence of malaria infection (mild or asymptomatic) ( 31667592) Recurrence of mild malaria attacks ( 31667592) Serum bilirubin levels x Mediterranean diet adherence interaction in metabolic syndrome ( 30621171) Systolic blood pressure ( 27841878) Temporal pole volume ( 31530798) Urate levels in obese individuals ( 25811787) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Weight ( 28552196)
Interacting Genes		12 interacting genes: AGTR1 CTH FPGT GTPBP4 IKBKE NOC2L PHOX2B PTGDS PTGER1 PTGER2 PTGES2 PTPRT	7 interacting genes: EGFR ERBB2 ERBB4 IL17RA PTGFR PTPRN SRC
Entrez ID		5737	11122
HPRD ID		08988	06690
Ensembl ID		ENSG00000122420	ENSG00000196090
Uniprot IDs		P43088	A0A075B6H0 O14522
PDB IDs			2OOQ
Enriched GO Terms of Interacting Partners?
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