PTPRT and IL17RA

		PTPRT	IL17RA
Description		protein tyrosine phosphatase receptor type T	interleukin 17 receptor A
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding Protein Phosphatase Binding Protein Homodimerization Activity Alpha-catenin Binding Gamma-catenin Binding Cadherin Binding Delta-catenin Binding STAT Family Protein Binding	Protein Binding Interleukin-17 Receptor Activity
	Biological Process	Protein Dephosphorylation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Cellular Response To Interleukin-6 Negative Regulation Of Receptor Signaling Pathway Via STAT Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity	Adaptive Immune Response Inflammatory Response Cell Surface Receptor Signaling Pathway Response To Virus Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Innate Immune Response Positive Regulation Of Inflammatory Response Fibroblast Activation Interleukin-17-mediated Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Pathways			Interleukin-17 signaling
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 24951543) Anxiety and stress-related disorders ( 31116379) BMI x SSRI levels interaction in schizophrenia or bipolar disorder ( 33824429) Diastolic blood pressure ( 27841878) Diisocyanate-induced asthma ( 25918132) Eye morphology ( 29921221) Facial attractiveness (male raters) ( 30946739) Fractional exhaled nitric oxide (childhood) ( 24315451) Gastroesophageal reflux disease ( 34187846) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels in HIV infection ( 33109212) Hip circumference ( 28552196) Household income (MTAG) ( 31844048) Metabolite levels ( 23823483) Microalbuminuria ( 26631737) Periodontitis (Mean PAL) ( 24024966) Problematic alcohol use in trauma-exposed individuals ( 29082582) Recurrence of malaria infection (mild or asymptomatic) ( 31667592) Recurrence of mild malaria attacks ( 31667592) Serum bilirubin levels x Mediterranean diet adherence interaction in metabolic syndrome ( 30621171) Systolic blood pressure ( 27841878) Temporal pole volume ( 31530798) Urate levels in obese individuals ( 25811787) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Weight ( 28552196)	Blood protein levels ( 30072576 29875488 28240269) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Heschl's gyrus morphology ( 25130324) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) White blood cell count ( 32888494 27863252)
Interacting Genes		7 interacting genes: EGFR ERBB2 ERBB4 IL17RA PTGFR PTPRN SRC	7 interacting genes: BCL2L13 BID IL17A MTDH POTEH PTPRT TESK1
Entrez ID		11122	23765
HPRD ID		06690	10399
Ensembl ID		ENSG00000196090	ENSG00000177663
Uniprot IDs		A0A075B6H0 O14522	Q96F46
PDB IDs		2OOQ	3JVF 4HSA 4NUX 5N9B 5NAN
Enriched GO Terms of Interacting Partners?
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